About: Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds
Creator	Collisson, Ellen Drechsler, Yvonne Griggs, Lisa
Source	Elsevier; Medline; PMC
abstract	Abstract Resistance to respiratory pathogens, including coronavirus-induced infection and clinical illness in chickens has been correlated with the B (MHC) complex and differential ex vivo macrophage responses. In the current study, in vitro T lymphocyte activation measured by IFNγ release was significantly higher in B2 versus B19 haplotypes. AIV infection of macrophages was required to activate T lymphocytes and prior in vivo exposure of chickens to NP AIV plasmid enhanced responses to infected macrophages. This study suggests that the demonstrated T lymphocyte activation is in part due to antigen presentation by the macrophages as well as cytokine release by the infected macrophages, with B2 haplotypes showing stronger activation. These responses were present both in CD4 and CD8 T lymphocytes. In contrast, T lymphocytes stimulated by ConA showed greater IFNγ release of B19 haplotype cells, further indicating the greater responses in B2 haplotypes to infection is due to macrophages, but not T cells. In summary, resistance of B2 haplotype chickens appears to be directly linked to a more vigorous innate immune response and the role macrophages play in activating adaptive immunity.
has issue date	2017-02-28(xsd:dateTime)
bibo:doi	10.1016/j.dci.2016.09.013
bibo:pmid	27746172
has license	els-covid
sha1sum (hex)	8cc3ab35fde19a1e8e4ccff32b49ff7b9a9b42ea
schema:url	https://doi.org/10.1016/j.dci.2016.09.013
resource representing a document's title	Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds
has PubMed Central identifier	PMC7102680
has PubMed identifier	27746172
schema:publication	Developmental & Comparative Immunology
resource representing a document's body	covid:8cc3ab35fde19a1e8e4ccff32b49ff7b9a9b42ea#body_text
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