About: Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites

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About: Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites
Creator	Hu, Xiaoliang Qu, Liandong Li, Zhijie Tian, Jin Chen, Si Huang, Jiapei Kang, Hongtao Yin, Hang Zhang, Jikai
Source	Medline; PMC
abstract	Feline infectious peritonitis (FIP), caused by virulent feline coronavirus, is the leading infectious cause of death in cats. The type I interferon (type I IFN)-mediated immune responses provide host protection from infectious diseases. Several coronaviruses have been reported to evolve diverse strategies to evade host IFN response. However, whether feline infectious peritonitis virus (FIPV) antagonizes the type I IFN signaling remains unclear. In this study, we demonstrated that FIPV strain DF2 infection not only failed to induce interferon-β (IFN-β) and interferon-stimulated gene (ISG) production, but also inhibited Sendai virus (SEV) or polyinosinic-polycytidylic acid (poly(I:C))-induced IFN-β production. Subsequently, we found that one of the non-structural proteins encoded by the FIPV genome, nsp5, interrupted type I IFN signaling in a protease-dependent manner by cleaving the nuclear factor κB (NF-κB) essential modulator (NEMO) at three sites—glutamine132 (Q132), Q205, and Q231. Further investigation revealed that the cleavage products of NEMO lost the ability to activate the IFN-β promoter. Mechanistically, the nsp5-mediated NEMO cleavage disrupted the recruitment of the TRAF family member-associated NF-κB activator (TANK) to NEMO, which reduced the phosphorylation of interferon regulatory factor 3 (IRF3), leading to the inhibition of type I IFN production. Our research provides new insights into the mechanism for FIPV to counteract host innate immune response.
has issue date	2019-12-30(xsd:dateTime)
bibo:doi	10.3390/v12010043
bibo:pmid	31905881
has license	cc-by
sha1sum (hex)	8c9c650f233ed3a031c995a887d8dfbc8b41e78c
schema:url	https://doi.org/10.3390/v12010043
resource representing a document's title	Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites
has PubMed Central identifier	PMC7019732
has PubMed identifier	31905881
schema:publication	Viruses
resource representing a document's body	covid:8c9c650f233ed3a031c995a887d8dfbc8b41e78c#body_text
is schema:about of	named entity 'production' named entity 'mediated' named entity 'Our' named entity 'leading' named entity 'Production' named entity 'ABILITY TO' named entity 'TYPE I INTERFERON PRODUCTION' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'FACTOR' named entity 'INDUCE' named entity 'TYPE I IFN PRODUCTION' named entity 'INNATE IMMUNE RESPONSE' named entity 'STRAIN' named entity 'MEDIATED' named entity 'BUT' named entity 'STRATEGIES' named entity 'TYPE I' named entity 'GENE' named entity 'SITES' named entity 'LOST' named entity 'PRODUCTS' named entity 'MODULATOR' named entity 'PROVIDE' named entity 'INHIBITION' named entity 'INTERFERON ' named entity 'GENOME' named entity 'ACTIVATE' named entity 'CLEAVAGE' named entity 'CORONAVIRUSES' named entity 'REPORTED' named entity 'DEPENDENT' named entity 'DEMONSTRATED' named entity 'INFECTION' named entity 'RECRUITMENT' named entity 'DISRUPTED' named entity 'HOST' named entity 'CAUSE OF DEATH' named entity 'ENCODED' named entity 'ACTIVATOR' named entity 'ESSENTIAL' named entity 'HAVE' named entity 'TRAF FAMILY' named entity 'DF2' named entity 'PROTEASE' named entity 'INVESTIGATION' named entity 'IMMUNE RESPONSES' named entity 'FOUND' named entity 'INDUCED' named entity 'SIGNALING' named entity 'NEW' named entity 'MULTIPLE' named entity 'NUCLEAR' named entity 'RESPONSE' named entity 'FAILED' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'INTERFERON REGULATORY FACTOR 3' covid:arg/8c9c650f233ed3a031c995a887d8dfbc8b41e78c named entity 'PROTECTION' named entity 'IFN' named entity 'SENDAI VIRUS' named entity 'NEMO' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'INSIGHTS' named entity 'NSP5' named entity 'NEMO' named entity 'SITES' named entity 'REVEALED' named entity 'POLYINOSINIC-POLYCYTIDYLIC ACID' named entity 'UNCLEAR' named entity 'BAB' named entity 'PRODUCTION' named entity 'PHOSPHORYLATION' named entity 'FAMILY MEMBER'

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