About: Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections

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About: Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections
Creator	Vanhems, Philippe Bénet, Thomas Hoffmann, Jonathan Rakoto Andrianarivelo, Mala Rasamoelina, Tahinamandranto Rabezanahary, Henintsoa Maeder, Muriel Rakoto-Alson, Olivat Rakotoarivo, Andry Zafindraibe, Norosoa Raoelina Randriatiana, Martin
Source	Medline; PMC
abstract	BACKGROUND: In Madagascar, the last study on sickle cell disease (SCD) was done in the early 1980s. The country is known as endemic for malaria and respiratory infections. The main objective of this study was to estimate the prevalence of SCD; the secondary objective was to evaluate its association with malaria and respiratory infections. METHODS: This is a cross-sectional study which was carried out in a rural village in the south east coast of Madagascar between May 2011 and November 2013. Participants were children aged between 2–59 months presenting with fever measured by axillary temperature ≥37.5 °C at inclusion. Genotyping of haemoglobin S was done by PCR and malaria was diagnosed by Rapid Diagnostic Test. Research for viral and atypical bacterial respiratory pathogens was performed on nasopharyngeal swabs. Uni-and multivariate polytomous logistic regression was done to assess associations between microbiological results and SCD status, with HbAA phenotype as reference. RESULTS: A total of 807 children were analysed. Prevalence of SCD among febrile children was 2.4% (95% CI, 1.5–3.7%) and that of SCT was 23.8% (95% CI, 20.9–26.9%). There was no difference in the prevalence of malaria infection according to haemoglobin status (p = 0.3). Rhinovirus (22.5%), adenovirus (14.1%), and bocavirus (11.6%) were the most common respiratory pathogens detected. After univariate analysis, patients with SCD were more frequently infected by parechovirus (p = 0.01), while patients with SCT were more prone to RSV A or B infection (p = 0.01). After multivariate analysis, HbAS phenotype was associated with higher risk of RSV A and B infection compared to HbAA (adjusted OR = 1.9; 95% CI: 1.2–3.1, p = 0.009), while HbSS phenotype was associated with higher risk of parechovirus infection (adjusted OR = 6.0; 95% CI: 1.1–31.3, p = 0.03) compared to HbAA, independently of age, gender, period per quarter, and the other viruses. CONCLUSION: The prevalence of SCD among under-five children presenting with fever was high in the study population. No association was found between SCT and malaria but few viruses, especially parechovirus, seem to play an important role in the occurrence of pneumoniae among SCD patients.
has issue date	2016-12-01(xsd:dateTime)
bibo:doi	10.1186/s12878-016-0069-1
bibo:pmid	27980789
has license	cc-by
sha1sum (hex)	8c6ca63f974a55bcab6f773fc9cda85c938b93eb
schema:url	https://doi.org/10.1186/s12878-016-0069-1
resource representing a document's title	Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections
has PubMed Central identifier	PMC5134128
has PubMed identifier	27980789
schema:publication	BMC Hematol
resource representing a document's body	covid:8c6ca63f974a55bcab6f773fc9cda85c938b93eb#body_text
is schema:about of	named entity 'study' named entity 'rural' named entity 'COUNTRY' named entity 'ASSOCIATION' named entity 'ESTIMATE' named entity 'EVALUATE' named entity 'ENDEMIC' named entity 'RESPIRATORY INFECTIONS' named entity 'KNOWN' named entity 'SICKLE CELL DISEASE' named entity 'STUDY' named entity 'OBJECTIVE' named entity 'ITS' named entity 'MADAGASCAR' named entity 'SICKLE-CELL DISEASE' named entity 'EARLY' named entity 'MAIN' named entity 'RESPIRATORY INFECTIONS' named entity 'SCD' named entity 'ASSOCIATION' named entity 'MADAGASCAR' named entity 'FEBRILE' named entity 'CHILDREN LIVING' named entity 'MALARIA' named entity 'SECONDARY OBJECTIVE' named entity 'MALARIA' named entity 'PREVALENCE' named entity 'RURAL VILLAGE' named entity 'BACKGROUND' covid:arg/8c6ca63f974a55bcab6f773fc9cda85c938b93eb named entity 'malaria' named entity 'malaria' named entity 'SCD' named entity 'endemic' named entity 'rural village' named entity 'malaria' named entity 'statistical difference' named entity 'SCD' named entity 'control group' named entity 'SCT' named entity 'endemic' named entity 'early death' named entity 'SCD' named entity 'asymptomatic carrier' named entity 'UNICEF' named entity 'coinfection' named entity 'epidemiology' named entity 'Rapid Diagnostic Test' named entity 'Centers for Disease Control and Prevention' named entity 'median age' named entity 'Lyon' named entity 'Africa' named entity 'study population' named entity 'Cameroon' named entity 'weight gain' named entity 'endemicity' named entity 'febrile' named entity 'microbiological' named entity 'Sebia' named entity 'India' named entity 'S. pneumoniae' named entity 'SCD' named entity 'malaria infection' named entity 'control group' named entity 'acute respiratory infection' named entity 'one-way analysis of variance' named entity 'India' named entity 'RFLP' named entity 'febrile illness' named entity 'blood samples' named entity 'real-time PCR'

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