About: Phenotypic switch of CD8(+) T cells reactivated under hypoxia toward IL‐10 secreting, poorly proliferative effector cells

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About: Phenotypic switch of CD8(+) T cells reactivated under hypoxia toward IL‐10 secreting, poorly proliferative effector cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phenotypic switch of CD8(+) T cells reactivated under hypoxia toward IL‐10 secreting, poorly proliferative effector cells
Creator	Dietrich, Pierre-Yves Walker, Paul Derouazi, Madiha Ducimetière, Laura Maroun, Yacoub Vuillefroy De Silly, Romain
Source	Medline; PMC
abstract	CD8(+) T cells controlling pathogens or tumors must function at sites where oxygen tension is frequently low, and never as high as under atmospheric culture conditions. However, T‐cell function in vivo is generally analyzed indirectly, or is extrapolated from in vitro studies under nonphysiologic oxygen tensions. In this study, we delineate the role of physiologic and pathologic oxygen tension in vitro during reactivation and differentiation of tumor‐specific CD8(+) T cells. Using CD8(+) T cells from pmel‐1 mice, we observed that the generation of CTLs under 5% O(2), which corresponds to physioxia in lymph nodes, gave rise to a higher effector signature than those generated under atmospheric oxygen fractions (21% O(2)). Hypoxia (1% O(2)) did not modify cytotoxicity, but decreasing O(2) tensions during CTL and CD8(+) tumor‐infiltrating lymphocyte reactivation dose‐dependently decreased proliferation, induced secretion of the immunosuppressive cytokine IL‐10, and upregulated the expression of CD137 (4‐1BB) and CD25. Overall, our data indicate that oxygen tension is a key regulator of CD8(+) T‐cell function and fate and suggest that IL‐10 release may be an unanticipated component of CD8(+) T cell‐mediated immune responses in most in vivo microenvironments.
has issue date	2015-05-26(xsd:dateTime)
bibo:doi	10.1002/eji.201445284
bibo:pmid	25929785
has license	no-cc
sha1sum (hex)	8c63eb3a5dc25f0a67c630ab3d3ca60b135305e9
schema:url	https://doi.org/10.1002/eji.201445284
resource representing a document's title	Phenotypic switch of CD8(+) T cells reactivated under hypoxia toward IL‐10 secreting, poorly proliferative effector cells
has PubMed Central identifier	PMC7163737
has PubMed identifier	25929785
schema:publication	Eur J Immunol
resource representing a document's body	covid:8c63eb3a5dc25f0a67c630ab3d3ca60b135305e9#body_text
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