About: PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study
Creator	Dove, Winifred Kelsall, Angela West, Peter Uk, Bishop, Bishop@uhsm, Paul Decalmer, Dove@liverpool, W Kelsall@manchester, Angela Smith, Smith@manchester, Jacky Stewart, Stewart@liverpool, J Uk, Ashley Uk, Jaclyn Uk, James Uk, Paul Uk, Samantha Woodcock, Woodcock@manchester, Ashley
Source	Medline; PMC
abstract	BACKGROUND: Viral respiratory tract infection is the most frequent cause of acute cough and is reported at onset in about one third of patients with chronic cough. Persistent infection is therefore one possible explanation for the cough reflex hypersensitivity and pulmonary inflammation reported in chronic cough patients. METHODS: Bronchoscopic endobronchial biopsies and bronchoalveolar lavage cell counts were obtained from ten healthy volunteers and twenty treatment resistant chronic cough patients (10 selected for lavage lymphocytosis). A screen for known respiratory pathogens was performed on biopsy tissue. Chronic cough patients also underwent cough reflex sensitivity testing using citric acid. RESULTS: There was no significant difference in incidence of infection between healthy volunteers and chronic cough patients (p = 0.115) or non-lymphocytic and lymphocytic groups (p = 0.404). BAL cell percentages were not significantly different between healthy volunteers and chronic cough patients without lymphocytosis. Lymphocytic patients however had a significantly raised percentage of lymphocytes (p < 0.01), neutrophils (p < 0.05), eosinophils (p < 0.05) and decreased macrophages (p < 0.001) verses healthy volunteers. There was no significant difference in the cough reflex sensitivity between non-lymphocytic and lymphocytic patients (p = 0.536). CONCLUSIONS: This study indicates latent infection in the lung is unlikely to play an important role in chronic cough, but a role for undetected or undetectable pathogens in either the lung or a distal site could not be ruled out. TRIALS REGISTRATION: Current Controlled Trials ISRCTN62337037 & ISRCTN40147207
has issue date	2012-09-14(xsd:dateTime)
bibo:doi	10.1186/1745-9974-8-5
bibo:pmid	22978556
has license	cc-by
sha1sum (hex)	8c5bd7a3606dc60cc568fb2614c8a5bdc00bffbb
schema:url	https://doi.org/10.1186/1745-9974-8-5
resource representing a document's title	PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study
has PubMed Central identifier	PMC3496690
has PubMed identifier	22978556
schema:publication	Cough
resource representing a document's body	covid:8c5bd7a3606dc60cc568fb2614c8a5bdc00bffbb#body_text
is schema:about of	named entity 'BASED' named entity 'COMMON' named entity 'RESPIRATORY PATHOGENS' named entity 'PCR' named entity 'BRONCHOSCOPIC' named entity 'DETECTION' named entity 'CHRONIC COUGH' named entity 'CASE CONTROL STUDY' named entity 'chronic cough' named entity 'case control study' named entity 'viruses' named entity 'VZV' named entity 'phosphoprotein' named entity 'adenovirus' named entity 'gene' named entity 'Mycoplasma pneumoniae' named entity 'HBoV' named entity 'primers' named entity 'virus' named entity 'Influenza' named entity 'primers' named entity 'OC43' named entity 'NL63' named entity 'primers' named entity 'Influenza' named entity 'primers' named entity 'gene' named entity 'primers' named entity 'sense 5' named entity 'primers' named entity 'Coronavirus' named entity 'negative sense' named entity 'DNA polymerase' named entity 'gene' named entity 'EBV' named entity 'Adenovirus' named entity 'primers' named entity 'NL63' named entity 'HKU1' named entity 'primers' named entity 'nonstructural protein' named entity 'OC43' named entity 'PCR' named entity 'Human metapneumovirus' named entity 'anti-sense' named entity 'Epstein-Barr virus' named entity 'Mycoplasma pneumoniae' named entity 'PCR' named entity 'Human bocavirus' named entity 'Human coronaviruses' named entity 'PCR' named entity 'RT-PCR' named entity 'Rhinovirus' named entity 'gene' named entity 'Respiratory Syncytial Virus' named entity 'biopsies' named entity 'HBoV' named entity 'MGB' named entity 'gene' named entity 'RT-PCR' named entity 'Human Bocavirus' named entity 'RT-PCR'

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