About: Pan-cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS-CoV-2 infection leading to COVID-19

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About: Pan-cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS-CoV-2 infection leading to COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pan-cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS-CoV-2 infection leading to COVID-19
Creator	Spandidos, Demetrios Anikin, Vladimir Chatha, Kamaljit Karteris, Emmanouil Katopodis, Periklis Kyrou, Ioannis Randeva, Harpal Biosciences,
source	Medline; PMC; WHO
abstract	Severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2) is the cause of a new disease (COVID-19) which has evolved into a pandemic during the first half of 2020. Older age, male sex and certain underlying diseases, including cancer, appear to significantly increase the risk for severe COVID-19. SARS-CoV-2 infection of host cells is facilitated by the angiotensin-converting enzyme 2 (ACE-2), and by transmembrane protease serine 2 (TMPRSS2) and other host cell proteases such as cathepsin L (CTSL). With the exception of ACE-2, a systematic analysis of these two other SARS-CoV2 infection mediators in malignancies is lacking. Here, we analysed genetic alteration, RNA expression, and DNA methylation of TMPRSS2 and CTSL across a wide spectrum of tumors and controls. TMPRSS2 was overexpressed in cervical squamous cell carcinoma and endocervical adenocarcinoma, colon adenocarcinoma, prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), uterine corpus endometrial carcinoma and uterine carcinosarcoma, with PRAD and READ exhibiting the highest expression of all cancers. CTSL was upregulated in lymphoid neoplasm diffuse large B-cell lymphoma, oesophageal carcinoma, glioblastoma multiforme, head and neck squamous cell carcinoma, lower grade glioma, pancreatic adenocarcinoma, skin cutaneous melanoma, stomach adenocarcinoma, and thymoma. Hypo-methylation of both genes was evident in most cases where they have been highly upregulated. We have expanded on our observations by including data relating to mutations and copy number alterations at pan-cancer level. The novel hypotheses that are stemming out of these data need to be further investigated and validated in large clinical studies.
has issue date	2020-05-26(xsd:dateTime)
bibo:doi	10.3892/ijo.2020.5071
bibo:pmid	32468052
has license	cc-by-nc-nd
sha1sum (hex)	8c28802af368ffb4e9e4ccd51c2f9975d9a946f8
schema:url	https://doi.org/10.3892/ijo.2020.5071
resource representing a document's title	Pan-cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS-CoV-2 infection leading to COVID-19
has PubMed Central identifier	PMC7307597
has PubMed identifier	32468052
schema:publication	Int J Oncol
resource representing a document's body	covid:8c28802af368ffb4e9e4ccd51c2f9975d9a946f8#body_text
is schema:about of	named entity 'evident' named entity 'clinical studies' named entity 'wide' named entity 'thymoma' named entity 'oesophageal' named entity 'prostate adenocarcinoma' named entity 'infection' named entity 'diseases' named entity 'cutaneous' named entity 'PRAD' named entity 'investigated' named entity 'squamous cell carcinoma' named entity 'adenocarcinoma' named entity 'relating' named entity 'PRAD' named entity 'host' named entity 'age' named entity 'coronavirus' named entity 'TMPRSS2' named entity 'neonatal' named entity 'PADD' named entity 'cathepsin' named entity 'prostate cancer' named entity 'lung tissue' named entity 'prostate' named entity 'methylation' named entity 'methylation' named entity 'adenocarcinoma' named entity 'transmembrane' named entity 'BRCA' named entity 'pheochromocytoma' named entity 'gene' named entity 'correlation' named entity 'angiotensin-converting enzyme 2' named entity 'methylation' named entity 'organ' named entity 'TMPRSS2' named entity 'host cell' named entity 'placentation' named entity 'viral proteins' named entity 'TMPRSS2' named entity 'COAD' named entity 'stomach adenocarcinoma' named entity 'colon' named entity 'bladder urothelial carcinoma' named entity 'viral proteins' named entity 'thyroid carcinoma' named entity 'COVID' named entity 'methylation' named entity 'diabetes' named entity 'transmembrane' named entity 'TMPRSS2' named entity 'TCGA' named entity 'coronavirus' named entity 'TMPRSS2' named entity 'COAD' named entity 'TMPRSS2' named entity 'data' named entity 'glioblastoma multiforme' named entity 'RNA' named entity 'cell' named entity 'transmembrane' named entity 'protease' named entity 'uterine carcinosarcoma' named entity 'SARS-CoV2' named entity 'underlying diseases' named entity 'ACE-2' named entity 'RNA' named entity 'Severe acute respiratory syndrome' named entity 'malignancies' named entity 'coronavirus' named entity 'uterine carcinosarcoma' named entity 'skin cutaneous melanoma' named entity 'ACE-2'

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