About: Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats

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About: Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats
Creator	Deng, Yu Li, Miao-Ling Tan, Xing Wang, Wei-Zhong Wang, Yang-Kai
Source	PMC
abstract	The rostral ventrolateral medulla (RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. The purpose of this study was to determine the effect of ACE2 overexpression in the RVLM on cholinergic synaptic transmission in spontaneously hypertensive rats (SHRs). Four weeks after injecting lentiviral particles containing enhanced green fluorescent protein and ACE2 bilaterally into the RVLM, the blood pressure and heart rate were notably decreased. ACE2 overexpression significantly reduced the concentration of acetylcholine in microdialysis fluid from the RVLM and blunted the decrease in blood pressure evoked by bilateral injection of atropine into the RVLM in SHRs. In conclusion, we suggest that ACE2 overexpression in the RVLM attenuates the enhanced cholinergic synaptic transmission in SHRs.
has issue date	2018-10-15(xsd:dateTime)
bibo:doi	10.1007/s12264-018-0298-3
bibo:pmid	30318562
has license	no-cc
sha1sum (hex)	8c198653c7db388f64662e77fd74bf62bacbf0a5
schema:url	https://doi.org/10.1007/s12264-018-0298-3
resource representing a document's title	Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats
has PubMed Central identifier	PMC6357273
has PubMed identifier	30318562
schema:publication	Neurosci Bull
resource representing a document's body	covid:8c198653c7db388f64662e77fd74bf62bacbf0a5#body_text
is schema:about of	named entity 'ACE2' named entity 'synaptic transmission' named entity 'hypertensive' named entity 'acetylcholine' named entity 'beneficial' named entity 'bilateral' named entity 'weeks' named entity 'function' named entity 'brain' named entity 'fluorescent protein' named entity 'blood pressure' named entity 'Signaling' named entity 'rostral ventrolateral medulla' named entity 'RVLM' named entity 'RVLM' named entity 'atropine' named entity 'cholinergic' named entity 'green fluorescent protein' named entity 'Cardiovascular' named entity 'Angiotensin-Converting Enzyme 2' named entity 'Rostral Ventrolateral Medulla' named entity 'conjugated' named entity 'normotensive' named entity 'ACE2' named entity 'central nervous' named entity 'cloning' named entity 'ACE2' named entity 'lentivirus' named entity 'VAChT' named entity 'RVLM' named entity 'hypertension' named entity 'hypertension' named entity 'sympathetic nerves' named entity 'arterial pressure' named entity 'VAChT' named entity 'neurons' named entity 'RVLM' named entity 'Triton X-100' named entity 'centrifugation' named entity 'ChAT' named entity 'neurons' named entity 'RVLM' named entity 'RVLM' named entity 'sympathetic outflow' named entity 'VAChT' named entity 'microdialysis' named entity 'receptor' named entity 'RVLM' named entity 'ACE2' named entity 'Enhanced expression' named entity 'antibodies' named entity 'isoflurane' named entity 'cardiovascular' named entity 'RVLM' named entity 'urethane' named entity 'mAChRs' named entity 'ACh' named entity 'nuclei' named entity 'monohydrate' named entity 'RVLM' named entity 'ACE2' named entity 'adenosine' named entity 'metabolism' named entity 'synaptic transmission' named entity 'ACE2' named entity 'protein' named entity 'RVLM' named entity 'antihypertensive drugs' named entity 'ACE2' named entity 'Western blot' named entity 'intron' named entity 'Sarasota' named entity 'RVLM' named entity 'polyoxymethylene' named entity 'atropine' named entity 'WKY' named entity 'RVLM'

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