About: Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus

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About: Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus
Creator	Canard, Bruno Decroly, Etienne Imbert, Isabelle Sevajol, Marion Subissi, Lorenzo
Source	Elsevier; Medline; PMC
abstract	Abstract The successive emergence of highly pathogenic coronaviruses (CoVs) such as the Severe Acute Respiratory Syndrome (SARS-CoV) in 2003 and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012 has stimulated a number of studies on the molecular biology. This research has provided significant new insight into functions and activities of the replication/transcription multi-protein complex. The latter directs both continuous and discontinuous RNA synthesis to replicate and transcribe the large coronavirus genome made of a single-stranded, positive-sense RNA of ∼30kb. In this review, we summarize our current understanding of SARS-CoV enzymes involved in RNA biochemistry, such as the in vitro characterization of a highly active and processive RNA polymerase complex which can associate with methyltransferase and 3′–5′ exoribonuclease activities involved in RNA capping, and RNA proofreading, respectively. The recent discoveries reveal fascinating RNA-synthesizing machinery, highlighting the unique position of coronaviruses in the RNA virus world.
has issue date	2014-12-19(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2014.10.008
bibo:pmid	25451065
has license	els-covid
sha1sum (hex)	8c10cdea8b892f4e8824fa062b1a586db8246f19
schema:url	https://doi.org/10.1016/j.virusres.2014.10.008
resource representing a document's title	Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus
has PubMed Central identifier	PMC7114481
has PubMed identifier	25451065
schema:publication	Virus Research
resource representing a document's body	covid:8c10cdea8b892f4e8824fa062b1a586db8246f19#body_text
is schema:about of	named entity 'insight' named entity 'continuous' named entity 'MERS-CoV' named entity 'replicate' named entity 'RNA' named entity 'CORONAVIRUS' named entity 'CONTINUOUS' named entity 'SENSE' named entity 'SIGNIFICANT' named entity 'STIMULATED' named entity 'MECHANISMS' named entity 'INSIGHTS' named entity 'RNA SYNTHESIS' named entity 'PROOFREADING' named entity 'EMERGENCE' named entity 'DISCONTINUOUS' named entity 'REPLICATION' named entity 'INSIGHT' named entity 'CORONAVIRUS' named entity 'CAPPING' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'HIGHLY' named entity 'FUNCTIONS' named entity 'SARS' named entity 'POSITIVE' named entity 'ACTIVITIES' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'PROTEIN COMPLEX' named entity 'NUMBER OF' named entity 'MULTI' named entity 'GENOME' named entity 'RNA SYNTHESIS' named entity 'SINGLE' named entity 'PROVIDED' named entity 'CORONAVIRUSES' named entity 'MOLECULAR BIOLOGY' named entity 'RESEARCH' named entity 'PATHOGENIC' named entity 'STUDIES' named entity 'LARGE' named entity 'NEW' named entity 'REPLICATE' named entity 'SUCCESSIVE' covid:arg/8c10cdea8b892f4e8824fa062b1a586db8246f19 named entity 'discontinuous' named entity 'stimulated' named entity 'Middle East Respiratory Syndrome Coronavirus' named entity 'successive' named entity 'studies' named entity 'RNA' named entity 'SARS-CoV' named entity 'proofreading' named entity 'coronavirus' named entity 'transmembrane domains' named entity 'aurintricarboxylic acid' named entity 'dsRNA' named entity 'RNA' named entity 'N-terminus' named entity 'coronavirus' named entity 'processive' named entity 'innate immune' named entity 'MHV' named entity 'nested set' named entity 'transmembrane proteins' named entity 'vaccinia virus' named entity 'mRNA' named entity 'exonuclease activity' named entity 'molecule' named entity 'conserved motifs' named entity 'complex formation' named entity 'Nidovirales' named entity 'guanosine monophosphate' named entity 'virus' named entity 'antibodies' named entity 'SARS-CoV' named entity 'nucleotide' named entity 'bi-molecular'

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