About: Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness
Creator	Nissen, Michael Sloots, Theo Sorrell, Tania Dwyer, Dominic Mackay, Ian Faux, Cassandra Ferguson, Patricia Gilroy, Nicole
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: A previously unidentified species of human rhinovirus, HRV-C, was described in 2006 in association with lower respiratory tract infection (LRTI). Features of infection in immunosuppressed adults are poorly characterised. OBJECTIVES: This study aims to determine the epidemiology of HRV-C in haematopoietic stem cell transplant (HSCT) recipients in a single centre. STUDY DESIGN: A prospective cohort study of all HSCT recipients admitted to Westmead Hospital, Westmead, Australia from 1 July 2005 to 30 September 2007 was undertaken. Nose/throat samples were collected from all patients at the time of admission and patients developing pre-defined symptoms and/or signs of respiratory infection during the admission. Samples were processed and tested for rhinoviruses and 14 other respiratory viruses using nucleic acid-based methods, immunofluorescence and culture. HRV genotyping was performed by sequencing a region of the rhinovirus 5′ untranslated region (UTR). Clinical data on each episode were collected prospectively. RESULTS: HRVs were identified in 24 episodes: 8% of 299 episodes of clinically- defined respiratory infections and 39% of 61 episodes in which respiratory viruses were detected. HRV-C was most frequent (HRV-C: nine, HRV-A: eight and HRV-B: two). Seven episodes of HRV-C, five with pneumonia, occurred within 100 days of HSCT. Co-pathogens were frequent. CONCLUSIONS: The newly described HRV-C was the most common rhinovirus group detected in HSCT recipients with respiratory infection, with co-pathogens being frequent. Further research is required to understand the activity and pathogenicity of this virus in HSCT recipients.
has issue date	2013-01-03(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2012.11.010
bibo:pmid	23290385
has license	no-cc
sha1sum (hex)	8bb97f186e7855381df305f55156b88182fcc465
schema:url	https://doi.org/10.1016/j.jcv.2012.11.010
resource representing a document's title	Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness
has PubMed Central identifier	PMC7172717
has PubMed identifier	23290385
schema:publication	J Clin Virol
resource representing a document's body	covid:8bb97f186e7855381df305f55156b88182fcc465#body_text
is schema:about of	named entity 'haematopoietic stem cell' named entity 'virus' named entity 'pneumonia' named entity 'complementary DNA' named entity 'HRV' named entity 'HSCT' named entity 'virus' named entity 'HRV' named entity 'PCR' named entity 'HRV' named entity 'respiratory symptoms' named entity 'HSCT' named entity 'Sequence analysis' named entity 'immunosuppression' named entity 'Copan' named entity 'clinical features' named entity 'HSCT' named entity 'Bronchoalveolar lavage' named entity 'HRV' named entity 'pneumonia' named entity 'outpatient' named entity 'assay' named entity 'runny nose' named entity 'EV-D68' named entity 'HRV' named entity 'Symptom' named entity 'HRV' named entity 'nursing staff' named entity 'virus infection' named entity 'nosocomially' named entity 'viruses' named entity 'polymerase chain reaction' named entity 'HRV' named entity 'invasive aspergillosis' named entity 'upper respiratory' named entity 'chest X-ray' named entity 'oxygen saturation' named entity 'C11' named entity 'pathogenicity' named entity 'transport medium' named entity 'HRV' named entity 'rhinorrhoea' named entity 'HSCT' named entity 'HRV' named entity 'respiratory tract' named entity 'wheezing' named entity 'QIAGEN' named entity 'pneumonia' named entity 'HRV' named entity 'renal transplant' named entity 'immunosuppression' named entity 'hot-start' named entity 'pathogens' named entity 'nucleotide' named entity 'HRV' named entity 'epidemiology' named entity 'pneumonia' named entity 'infection' named entity 'picornavirus' named entity 'HSCT' named entity 'lower respiratory' named entity 'enterovirus' named entity 'HRV' named entity 'haematology' named entity 'HRV' named entity 'clinician' named entity 'radiological imaging' named entity 'nucleotides' named entity 'cDNA' named entity 'URTIs' named entity 'pneumonia' named entity 'viruses' named entity 'allogeneic' named entity 'renal transplant'

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