About: Two novel regulators of N‐acetyl‐galactosamine utilization pathway and distinct roles in bacterial infections

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About: Two novel regulators of N‐acetyl‐galactosamine utilization pathway and distinct roles in bacterial infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Two novel regulators of N‐acetyl‐galactosamine utilization pathway and distinct roles in bacterial infections
Creator	Wang, Changjun Hu, Dan Feng, Youjun Cao, Min Zhang, Huimin Gong, Xiufang Hao, Lina Zhang, Fengyu Ravcheev, Dmitry Rodionov, Dmitry
Source	PMC
abstract	Bacterial pathogens can exploit metabolic pathways to facilitate their successful infection cycles, but little is known about roles of d‐galactosamine (GalN)/N‐acetyl‐d‐galactosamine (GalNAc) catabolism pathway in bacterial pathogenesis. Here, we report the genomic reconstruction of GalN/GalNAc utilization pathway in Streptococci and the diversified aga regulons. We delineated two new paralogous AgaR regulators for the GalN/GalNAc catabolism pathway. The electrophoretic mobility shift assays experiment demonstrated that AgaR2 (AgaR1) binds the predicted palindromes, and the combined in vivo data from reverse transcription quantitative polymerase chain reaction and RNA‐seq suggested that AgaR2 (not AgaR1) can effectively repress the transcription of the target genes. Removal of agaR2 (not agaR1) from Streptococcus suis 05ZYH33 augments significantly the abilities of both adherence to Hep‐2 cells and anti‐phagocytosis against RAW264.7 macrophage. As anticipated, the dysfunction in AgaR2‐mediated regulation of S. suis impairs its pathogenicity in experimental models of both mice and piglets. Our finding discovered two novel regulators specific for GalN/GalNAc catabolism and assigned them distinct roles into bacterial infections. To the best of our knowledge, it might represent a first paradigm that links the GalN/GalNAc catabolism pathway to bacterial pathogenesis.
has issue date	2015-11-05(xsd:dateTime)
bibo:doi	10.1002/mbo3.307
bibo:pmid	26540018
has license	cc-by
sha1sum (hex)	8bae8e6308d50b3a053a98be3b0fd641c775c1ca
schema:url	https://doi.org/10.1002/mbo3.307
resource representing a document's title	Two novel regulators of N‐acetyl‐galactosamine utilization pathway and distinct roles in bacterial infections
has PubMed Central identifier	PMC4694137
has PubMed identifier	26540018
schema:publication	Microbiologyopen
resource representing a document's body	covid:8bae8e6308d50b3a053a98be3b0fd641c775c1ca#body_text
is schema:about of	named entity 'Hep' named entity 'experimental' named entity 'catabolism' named entity 'Removal' named entity 'utilization' named entity 'TRANSCRIPTION' named entity 'REGULATION' named entity 'AGAR' named entity 'CATABOLISM' named entity 'ITS' named entity 'METABOLIC PATHWAYS' named entity 'REPRESENT' covid:arg/8bae8e6308d50b3a053a98be3b0fd641c775c1ca named entity 'AGA' named entity 'KNOWLEDGE' named entity 'LITTLE' named entity 'EXPLOIT' named entity 'FINDING' named entity 'HERE' named entity 'REGULATORS' named entity 'STREPTOCOCCUS SUIS 05ZYH33' named entity 'ASSIGNED' named entity 'GENES' named entity 'MICE' named entity 'PARALOGOUS' named entity 'ABILITIES' named entity 'REGULATORS' named entity 'DISTINCT' named entity 'REPORT' named entity 'UTILIZATION' named entity 'ABOUT' named entity 'GENOMIC' named entity 'SUCCESSFUL' named entity 'DYSFUNCTION' named entity 'PATHWAY' named entity 'GALACTOSAMINE' named entity 'BACTERIAL INFECTIONS' named entity 'UTILIZATION' named entity 'ROLES' named entity 'PHAGOCYTOSIS' named entity 'GALACTOSAMINE' named entity 'REGULONS' named entity 'RNA-SEQ ' named entity 'BACTERIAL' named entity 'RECONSTRUCTION' named entity 'DELINEATED' named entity 'PARADIGM' named entity 'REVERSE TRANSCRIPTION QUANTITATIVE POLYMERASE CHAIN REACTION' named entity 'TARGET' named entity 'SPECIFIC' named entity 'RAW264.7' named entity 'PATHWAY' named entity 'PATHOGENESIS' named entity 'D-GALACTOSAMINE' named entity 'LINKS' named entity 'IN VIVO' named entity 'BUT' named entity 'BACTERIAL PATHOGENS' named entity 'DATA' named entity 'BINDS' named entity 'THEIR' named entity 'BACTERIAL INFECTIONS' named entity 'EXPERIMENT' named entity 'ADHERENCE' named entity 'COMBINED' named entity 'REMOVAL' named entity 'IMPAIRS' named entity 'MACROPHAGE' named entity 'ANTICIPATED' named entity 'PREDICTED' named entity 'STREPTOCOCCI' named entity 'ELECTROPHORETIC MOBILITY SHIFT ASSAYS'

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