About: Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China
Creator	Zang, Guo-Qing Wu, Jing Xu, Jie Li, Yang Xu, Teng Ai, Jing-Wen Zhang, Hao-Cheng Zhang, Wen-Hong Li, Yong-Jun Chen, Jia-Zhen Chen, Wen-Jing Shen, Zhongliang Sun, Jing-Ying Xie, De-Sheng Yu, Yi-Qi Zhang, Han-Yue Zhou, Ming-Zhe Zhou, Xian Zhu, Mengqi
Source	MedRxiv
abstract	COVID-19 caused by a novel coronavirus SARS-CoV-2 emerged in Wuhan, Hubei province since December 2019, and caused a rapid outbreak throughout China and globally. Cities outside Hubei are also facing great challenge and require implementing of effective and feasible strategy in precision diagnosing novel coronavirus pneumonia (NCP). We described a multicenter prospective study on diagnostic strategy of suspected NCP patients from January 22nd to February 9th, 2020 in Eastern China cities. Nasopharyngeal swabs were collected from the patients. The epidemiological characteristics, clinical symptoms, laboratory assessments, and computed tomographic (CT) scans were obtained. Pathogen screen were performed including RT-PCR, multiplex PCR, rapid flu antigen tests and mNGS. We enrolled 53 suspected NCP patients, among whom 20 were laboratory-confirmed. Fourteen (70%) and 3 (15%) patients were positive for the first and second SARS-CoV-2 RT-PCR test, respectively. All NCP patients were positive for mNGS. Chest CT images and the symptoms of early stage NCP patients were similar to other viral pneumonia patients. We identified 11 of 20 co-infections in NCP cases, including regular respiratory virus, fungi and bacteria synchronously. Genomic analysis showed that 8 of 10 cases had no mutation in virus genome, while 2 cases had only one single mutation in N gene. Our study discovered that a combination of chest CT, SARS-CoV-2 RT-PCR and multi-plex PCR is recommended in regions outside Hubei province. Co-infection of other pathogens with SARS-CoV-2 exists and should be acknowledged. Repeated sampling, change of specimen type or metagenomics sequencing could further facilitate during critical clinical cases.
has issue date	2020-02-17(xsd:dateTime)
bibo:doi	10.1101/2020.02.13.20022673
has license	medrxiv
sha1sum (hex)	8b71ce92ec03e066eca7792bfd17e2f210d50ce3
schema:url	https://doi.org/10.1101/2020.02.13.20022673
resource representing a document's title	Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China
resource representing a document's body	covid:8b71ce92ec03e066eca7792bfd17e2f210d50ce3#body_text
is schema:about of	covid:arg/8b71ce92ec03e066eca7792bfd17e2f210d50ce3 named entity 'Wuhan' named entity 'strategy' named entity 'coronavirus' named entity 'caused' named entity 'medRxiv' named entity 'epidemiological' named entity 'pneumonia' named entity 'enterovirus' named entity 'pneumonia' named entity 'Hubei' named entity 'NCP' named entity 'coronavirus' named entity 'email' named entity 'SPAdes' named entity 'oxygen saturation' named entity 'parainfluenza virus' named entity 'multiplexed' named entity 'Metagenomic sequencing' named entity 'preprint' named entity 'molecular evolution' named entity 'Phylogenetic trees' named entity 'genetic drift' named entity 'NCP' named entity 'metagenomics' named entity 'RT-PCR' named entity 'Nasopharyngeal swab' named entity 'nasopharyngeal swab' named entity 'critical stage' named entity 'Wuhan' named entity 'viruses' named entity 'COVID' named entity 'electronic medical records' named entity 'C. glabrata' named entity 'peer-reviewed' named entity 'mutation' named entity 'preprint' named entity 'co-infected' named entity 'pathogens' named entity 'SARS-COV-2' named entity 'QIAGEN' named entity 'Hubei' named entity 'Hubei Province' named entity 'SARS-COV-2' named entity 'white blood cell counts' named entity 'RT-PCR' named entity 'preprint' named entity 'turnaround time' named entity 'lymphocytes' named entity 'NCP' named entity 'medRxiv' named entity 'pathogens' named entity 'SARS-COV-2' named entity 'unilateral or bilateral' named entity 'coronavirus' named entity 'infection' named entity 'virus' named entity 'preprint' named entity 'medRxiv' named entity 'interquartile range' named entity 'epidemics' named entity 'pathogenic microorganisms' named entity 'clinical practice' named entity 'ground-glass opacity' named entity 'metagenomic sequencing' named entity 'NCP' named entity 'NCP'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software