About: Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis

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About: Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis
Creator	Lin, Ming Yip, Cyril Hung, Ivan Leung, Kit-Hang Chan, P Ho, ; Leung, Leung, K To, K Yip, C Zhang, Anna Cheng, Ming Leung, Wai Tam, Anthony Tso, Eugene Liu, Raymond Mrcp, Mbbs Ng, Y Agnes, ; Aj, Zhang Ar, Tam Cc, Yip Chan, Kwok-H Chan, Kwok-Y Chan, Pierre Cheng, Anna Cheung, Ka Chu, Man Chung, Tom Cyril, ; Fn, Ivan Frcp, Mbbs Fung, Ricky Fung Bsc, Yim-Fong Fung, Yim-Fong Gastrointestinal, Hm, Cheng Kelvin, ; Kk, To Kwok, ; Leung, K-H Lin, Yansheng Lung, K Mrcp, Tam My, Chu Ng, Liu Pierre, ; Raymond, Anthony Rr, Zhang To, Kwok-H Tw, Chung Wai, ; Wk, Leung Yim-Fong, Agnes Yuen, -Y Yuen, Wai Zhang Msc, Ricky Zhang, Kelvin Zhang, Yansheng
Source	Elsevier; Medline; PMC
abstract	Abstract Background & Aims Infection with SARS-CoV-2 causes COVID-19, which has been characterized by fever, respiratory, and gastrointestinal symptoms as well as shedding of virus RNA into feces. We performed a systematic review and meta-analysis of published gastrointestinal symptoms and detection of virus in stool, and also summarized data from a cohort of patients with COVID-19 in Hong Kong. Methods We collected data from the cohort of patients with COVID-19 in Hong Kong (n=59; diagnosis from February 2 through Feb 29, 2020), and searched PubMed, Embase, Cochrane and three Chinese databases through March 11, 2020 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We analyzed pooled data on the prevalence of overall and individual gastrointestinal symptoms (anorexia, nausea, vomiting, diarrhea, and abdominal pain or discomfort) using a random effects model. Results Among the 59 patients with COVID-19 in Hong Kong, 15 patients (25.4%) had gastrointestinal symptoms and 9 patients (15.3%) had stool that tested positive for virus RNA. Stool viral RNA was detected in 38.5% and 8.7% among those with and without diarrhea, respectively (P=.02). The median fecal viral load was 5.1 log10cpm in patients with diarrhea vs 3.9 log10cpm in patients without diarrhea (P=.06). In a meta-analysis of 60 studies, comprising 4243 patients, the pooled prevalence of all gastrointestinal symptoms was 17.6% (95% CI, 12.3%–24.5%); 11.8% of patients with non-severe COVID-19 had gastrointestinal symptoms (95% CI, 4.1%–29.1%) and 17.1% of patients with severe COVID-19 had gastrointestinal symptoms (95% CI, 6.9%–36.7%). In the meta-analysis, the pooled prevalence of stool samples that were positive for virus RNA was 48.1% (95% CI, 38.3%–57.9%); of these samples, 70.3% of those collected after loss of virus from respiratory specimens tested positive for the virus (95% CI, 49.6%–85.1%). Conclusions In an analysis of data from the Hong Kong cohort of patients with COVID-19 and a meta-analysis of findings from publications, we found that 17.6% of patients with COVID-19 had gastrointestinal symptoms. Virus RNA was detected in stool samples from 48.1% patients—even in stool collected after respiratory samples tested negative. Healthcare workers should therefore exercise caution in collecting fecal samples or performing endoscopic procedures in patients with COVID-19—even during patient recovery.
has issue date	2020-04-03(xsd:dateTime)
bibo:doi	10.1053/j.gastro.2020.03.065
bibo:pmid	32251668
has license	els-covid
sha1sum (hex)	8b715b57aab3925658256a476e0b1ea50fc4ee38
schema:url	https://doi.org/10.1053/j.gastro.2020.03.065
resource representing a document's title	Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis
has PubMed Central identifier	PMC7194936
has PubMed identifier	32251668
schema:publication	Gastroenterology
resource representing a document's body	covid:8b715b57aab3925658256a476e0b1ea50fc4ee38#body_text
is schema:about of	named entity 'patient' named entity 'supervision' named entity 'Lung' named entity 'Liu' named entity 'Leung' named entity 'manifestations' named entity 'Review' named entity 'Manifestations' named entity 'SARS-CoV-2' named entity 'LIN' named entity 'FINAL' named entity 'PPY' named entity 'LABORATORY' named entity 'involved' named entity 'Chu' named entity 'Lung' named entity 'Lin' named entity 'Zhang' named entity 'manuscript' named entity 'concept' named entity 'manuscript' named entity 'IFN' named entity 'study'

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