About: Timing of Intubation and Mortality Among Critically Ill Coronavirus Disease 2019 Patients: A Single-Center Cohort Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Timing of Intubation and Mortality Among Critically Ill Coronavirus Disease 2019 Patients: A Single-Center Cohort Study
Creator	Blum, James Martin, Greg David, ; Adelman, Max Auld, Sara Caridi-Scheible, Mark Edwards, Johnathan Fazio, Jane Hernandez-Romieu, Alfonso Hockstein, Maxwell Jabaley, Craig Murphy, J Robichaux, Chad Romieu, Hernandez
Source	Medline; PMC
abstract	OBJECTIVES: Increasing time to mechanical ventilation and high-flow nasal cannula use may be associated with mortality in coronavirus disease 2019. We examined the impact of time to intubation and use of high-flow nasal cannula on clinical outcomes in patients with coronavirus disease 2019. DESIGN: Retrospective cohort study. SETTING: Six coronavirus disease 2019-specific ICUs across four university-affiliated hospitals in Atlanta, Georgia. PATIENTS: Adults with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection who received high-flow nasal cannula or mechanical ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among 231 patients admitted to the ICU, 109 (47.2%) were treated with high-flow nasal cannula and 97 (42.0%) were intubated without preceding high-flow nasal cannula use. Of those managed with high-flow nasal cannula, 78 (71.6%) ultimately received mechanical ventilation. In total, 175 patients received mechanical ventilation; 44.6% were female, 66.3% were Black, and the median age was 66 years (interquartile range, 56–75 yr). Seventy-six patients (43.4%) were intubated within 8 hours of ICU admission, 57 (32.6%) between 8 and 24 hours of admission, and 42 (24.0%) greater than or equal to 24 hours after admission. Patients intubated within 8 hours were more likely to have diabetes, chronic comorbidities, and higher admission Sequential Organ Failure Assessment scores. Mortality did not differ by time to intubation (≤ 8 hr: 38.2%; 8–24 hr: 31.6%; ≥ 24 hr: 38.1%; p = 0.7), and there was no association between time to intubation and mortality in adjusted analysis. Similarly, there was no difference in initial static compliance, duration of mechanical ventilation, or ICU length of stay by timing of intubation. High-flow nasal cannula use prior to intubation was not associated with mortality. CONCLUSIONS: In this cohort of critically ill patients with coronavirus disease 2019, neither time from ICU admission to intubation nor high-flow nasal cannula use were associated with increased mortality. This study provides evidence that coronavirus disease 2019 respiratory failure can be managed similarly to hypoxic respiratory failure of other etiologies.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.1097/ccm.0000000000004600
bibo:pmid	32804790
has license	no-cc
sha1sum (hex)	8b6cf579f78d891c3c11141e54049ed18f3204af
schema:url	https://doi.org/10.1097/ccm.0000000000004600
resource representing a document's title	Timing of Intubation and Mortality Among Critically Ill Coronavirus Disease 2019 Patients: A Single-Center Cohort Study
has PubMed Central identifier	PMC7448713
has PubMed identifier	32804790
schema:publication	Crit Care Med
resource representing a document's body	covid:8b6cf579f78d891c3c11141e54049ed18f3204af#body_text
is schema:about of	named entity 'received' named entity 'nasal cannula' named entity 'length' named entity 'female' named entity 'infection' named entity 'None' named entity '2019' named entity 'INTUBATION' named entity 'ASSOCIATED WITH' named entity 'MAIN RESULTS' named entity 'NO DIFFERENCE' named entity 'DID' named entity 'mortality' named entity 'cohort' named entity 'Med' named entity 'received' named entity 'mechanical ventilation' named entity 'intubation' named entity 'mechanical ventilation' named entity 'Care' named entity 'randomized trial' named entity 'lung' named entity 'COVID-19' named entity 'ICU' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'Adults' named entity 'nasal cannula' named entity 'stay' named entity 'managed' named entity 'Organ' named entity 'intubated' named entity 'Interventions' named entity 'mechanical ventilation' named entity 'critically ill patients' named entity 'mechanical ventilation' named entity 'intubated' named entity 'nasal cannula' named entity 'coronavirus disease 2019' named entity 'Intubation' named entity 'Cohort Study' named entity 'mechanical ventilation' named entity 'severe acute respiratory syndrome' named entity 'extract, transform, and load' named entity 'supplemental oxygen' named entity 'cohort studies' named entity 'informed consent' named entity 'intubation' named entity 'coronavirus disease 2019' named entity 'intubate' named entity 'ICU' named entity 'WBC' named entity 'mechanical ventilation' named entity 'personal protective equipment' named entity 'intubated' named entity 'C-reactive protein' named entity 'nasal cannula' named entity 'intubated' named entity 'ICU' named entity 'COVID-19' named entity 'body mass index' named entity 'World Health Organization' named entity 'clinical outcomes' named entity 'mechanical ventilation' named entity 'ICU' named entity 'ARDS' named entity '1.2' named entity 'respiratory failure' named entity 'intubation'

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