About: Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames

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About: Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames
Creator	Wang, Yong Yang, Liu Chen, Ke-Ping Luo, Zhi-Peng Mao, Jun-Ming Wang, Guang-Dong Yao, Qin
Source	Medline; PMC
abstract	The outbreak of COVID-19 has brought great threat to human health. Its causative agent is a severe acute respiratory syndrome-related coronavirus which has been officially named SARS-CoV-2. Here we report the discovery of extremely low CG abundance in its open reading frames. We found that CG reduction in SARS-CoV-2 is achieved mainly through mutating C/G into A/T, and CG is the best target for mutation. Meanwhile, 5′-untranslated region of SARS-CoV-2 has high CG content and is capable of forming an internal ribosome entry site (IRES) to recruit host ribosome for translating its RNA. These features allow SARS-CoV-2 to reproduce efficiently in host cells, because less energy is consumed in disrupting the stem-loops formed by its genomic RNA. Notably, genomes of cellular organisms also have very low CG abundance, suggesting that mutating C/G into A/T occurs universally in all life forms. Moreover, CG is the dinucleotide related to CpG island, mutational hotspot and single nucleotide polymorphism in cellular organisms. The relationship between these features is worthy of further investigations.
has issue date	2020-07-23(xsd:dateTime)
bibo:doi	10.1038/s41598-020-69342-y
bibo:pmid	32704018
has license	cc-by
sha1sum (hex)	8b67f5f9d47d2b424644f47fd58f0feeff045029
schema:url	https://doi.org/10.1038/s41598-020-69342-y
resource representing a document's title	Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames
has PubMed Central identifier	PMC7378049
has PubMed identifier	32704018
schema:publication	Sci Rep
resource representing a document's body	covid:8b67f5f9d47d2b424644f47fd58f0feeff045029#body_text
is schema:about of	named entity 'RNA' named entity 'high' named entity 'efficiently' named entity 'evolved' named entity 'CAUSATIVE AGENT' named entity 'CPG ISLAND' named entity 'ALLOW' named entity 'FORMED' named entity 'IRES' named entity 'outbreak' named entity 'abundance' named entity 'virulence' named entity 'RNA' named entity 'life forms' named entity 'single nucleotide polymorphism' named entity 'cellular organisms' named entity 'CpG' named entity 'cellular organisms' named entity 'SARS-CoV-2' named entity 'RNA' named entity 'host cells' named entity 'IRES' named entity 'SARS-CoV-2' named entity 'silent mutations' named entity 'codon' named entity 'virus' named entity 'ribosome' named entity 'Secondary structure' named entity 'viral genomes' named entity 'hydrogen bonds' named entity 'coronaviruses' named entity 'coronaviruses' named entity 'coronaviruses' named entity 'bat' named entity 'odds ratio' named entity 'Middle East respiratory syndrome' named entity 'evolution' named entity 'nucleotide' named entity 'archaea' named entity 'ribosomes' named entity 'closely related' named entity 'cytoplasm' named entity 'untranslated region' named entity 'odds ratio' named entity 'viral genome' named entity 'nucleotide' named entity 'chemokines' named entity 'stem-loops' named entity 'GGT' named entity 'odds ratio' named entity 'severe acute respiratory syndrome' named entity 'NL63' named entity 'virulence' named entity 'cellular organisms' named entity 'thymidylate' named entity 'codon' named entity 'odds ratio' named entity 'thymidylate' named entity 'ORFs' named entity '0.01' named entity 'RNA' named entity 'mutation' named entity 'alanine' named entity 'MERS' named entity 'thymidylate' named entity 'G/C' named entity 'ORFs' named entity 'genome' named entity 'MERS' named entity 'odds ratio' named entity 'Free energy' named entity 'SARS' named entity 'nucleotide' named entity 'hydrogen bonds' named entity 'host cells'

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