About: Prevalence of serum neutralizing antibodies to adenovirus type 5 (Ad5) and 41 (Ad41) in children is associated with age and sanitary conditions

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About: Prevalence of serum neutralizing antibodies to adenovirus type 5 (Ad5) and 41 (Ad41) in children is associated with age and sanitary conditions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Prevalence of serum neutralizing antibodies to adenovirus type 5 (Ad5) and 41 (Ad41) in children is associated with age and sanitary conditions
Creator	Guo, Xiao-Juan Han, Mei Jiang, Shuang-Ying Lu, Nan-Nan Lu, Zhuo-Zhuang Yang, Wei-Xiong Zhao, Jian-Hai Zhao, Sheng-Cang Zou, Xiao-Hui Lu, Z.-Z Lu, Zhong Qu, Dong Yi, Ba Zhao, S.-C
source	Elsevier; Medline; PMC
abstract	Abstract Neutralizing antibody (NAb) can dampen the immunogenicity of adenovirus (Ad) vector-based vaccine. Vector systems based on human adenovirus type 41 (Ad41) have been constructed and used to develop recombinant vaccines. Here, we attempted to study the seroprevalence of NAbs to Ad5 and Ad41 among children and adults in Qinghai province, China. The positive rates (titer⩾40) of Ad5 and Ad41 NAb in adults from Xining city were 75.7% and 94.7%, respectively. The moderate/high-positive rates (titer⩾160) of NAb were quite close between the two viruses in adults (70.4% for Ad5 and 73.5% for Ad41). Age-dependent increase of NAb seroprevalence was observed for both viruses in children. NAb-positive rate of Ad41 reached 50% at 3.3–4.6years of age for children from Chengxi district, Xining city, approximately 1.5years earlier than that of Ad5 did. Interestingly, NAb level was also associated with sanitary conditions among young children. For Ad5, 8–15% children (0.2–3.0years of age) from city or town, where the sanitations were relatively better, had moderate/high-positive NAb, while the same rate was 62% for children from villages. For Ad41, 22% children from city, 47% from town and 88% from villages possessed moderate/high-positive NAb. The possible influence of NAb titer distributions on the application of Ad41-vectored vaccines was discussed in detail. Our results suggested that children from places with poor sanitations should be included for comprehensive Ad NAb seroprevalence studies, and provided insights to the applications of Ad41 vectors.
has issue date	2016-11-04(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2016.09.043
bibo:pmid	27682509
has license	els-covid
sha1sum (hex)	8b0692d658956ecd8a6270a97e40fefff049db1e
schema:url	https://doi.org/10.1016/j.vaccine.2016.09.043
resource representing a document's title	Prevalence of serum neutralizing antibodies to adenovirus type 5 (Ad5) and 41 (Ad41) in children is associated with age and sanitary conditions
has PubMed Central identifier	PMC7115419
has PubMed identifier	27682509
schema:publication	Vaccine
resource representing a document's body	covid:8b0692d658956ecd8a6270a97e40fefff049db1e#body_text
is schema:about of	named entity 'vectors' named entity 'titer' named entity 'For' named entity 'AGE' named entity 'CITY' named entity 'HUMAN ADENOVIRUS TYPE 41' named entity 'APPLICATION' named entity 'WHERE' named entity 'INCREASE' named entity '2-3' named entity 'PROVIDED' named entity 'USED' named entity 'COMPREHENSIVE' named entity 'STUDIES' named entity 'CHILDREN' named entity 'POSSIBLE' named entity 'ATTEMPTED' named entity 'NEUTRALIZING ANTIBODY' named entity 'SEROPREVALENCE' named entity 'HAVE' named entity 'PREVALENCE' named entity 'VILLAGES' named entity 'ADENOVIRUS TYPE 5' named entity 'TOWN' named entity 'DISTRIBUTIONS' named entity 'VACCINE' named entity 'RECOMBINANT VACCINES' named entity 'BASED' named entity 'VACCINES' named entity 'RESULTS' named entity 'RATE' named entity 'VIRUSES' named entity 'ASSOCIATED WITH' named entity 'SERUM' named entity 'CHILDREN' named entity 'NEUTRALIZING ANTIBODIES' named entity 'APPLICATIONS' named entity '160' named entity 'CHINA' named entity 'MODERATE' named entity 'OBSERVED' named entity '40%' named entity 'VECTOR' named entity 'AGE' named entity 'ADULTS' named entity 'ADENOVIRUS' named entity 'CLOSE' named entity 'POSSESSED' named entity 'INSIGHTS' named entity 'PLACES' named entity 'CONSTRUCTED' named entity 'RATES' named entity 'FOR CHILDREN' named entity 'QINGHAI PROVINCE' named entity 'CHENGXI DISTRICT' named entity 'CONDITIONS' named entity '1.5' named entity 'DEPENDENT' named entity '3.3' named entity '3-4' named entity 'LEVEL' named entity 'YOUNG CHILDREN' named entity 'VECTORS' named entity '4.6' named entity 'INFLUENCE' named entity 'BETTER' named entity 'CITY OR TOWN' named entity 'TITER'

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