About: Insights into pathogenesis of fatal COVID‐19 pneumonia from histopathology with immunohistochemical and viral RNA studies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Insights into pathogenesis of fatal COVID‐19 pneumonia from histopathology with immunohistochemical and viral RNA studies
Creator	Selbs, Elena Taubenberger, Jeffery Travis, William Chang, Jason Kleiner, David Morjaria, Sejal Pittaluga, Stefania Rapkiewicz, Amy Sauter, Jennifer Butnor, Kelly Baine, Marina Buonocore, Darren Jungbluth, Achim Mount, Sharon Rekhtman, Natasha Sheng, Zong-Mei Szabolcs, Matthias Xiao, Yongli
Source	Medline; PMC
abstract	INTRODUCTION: We describe postmortem pulmonary histopathologic findings of COVID‐19 pneumonia in patients with a spectrum of disease course, from rapid demise to prolonged hospitalization. METHODS: Histopathologic findings in postmortem lung tissue from eight patients who died from COVID‐19 pneumonia were reviewed. Immunohistochemistry (IHC) and next generation sequencing (NGS) were performed to detect virus. RESULTS: Diffuse alveolar damage (DAD) was seen in all cases with a spectrum of acute phase and/or organizing phase. IHC with monoclonal antibodies against SARS‐CoV‐2 viral nucleoprotein and spike protein detected virus in areas of acute but not organizing DAD, with intracellular viral antigen and RNA expression seen predominantly in patients with duration of illness less than 10 days. Major vascular findings included thrombi in medium and large caliber vessels, platelet microthrombi detected by CD61 IHC, and fibrin microthrombi. CONCLUSIONS: Presence of SARS‐CoV‐2 viral RNA by NGS early in the disease course and expression of viral antigen by IHC exclusively in the acute but not in the organizing phase of DAD, suggests that the virus may play a major role in initiating the acute lung injury of DAD, but when DAD progresses to the organizing phase, the virus may have been cleared from the lung by the patient’s immune response. These findings suggest the possibility of a major change during the disease course of COVID‐19 pneumonia that may have therapeutic implications. Frequent thrombi and microthrombi may also present potential targets for therapeutic intervention.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1111/his.14201
bibo:pmid	32614086
has license	no-cc
sha1sum (hex)	8af886cbb577c75e2f484e4c9792148fbdc95399
schema:url	https://doi.org/10.1111/his.14201
resource representing a document's title	Insights into pathogenesis of fatal COVID‐19 pneumonia from histopathology with immunohistochemical and viral RNA studies
has PubMed Central identifier	PMC7361244
has PubMed identifier	32614086
schema:publication	Histopathology
resource representing a document's body	covid:8af886cbb577c75e2f484e4c9792148fbdc95399#body_text
is schema:about of	named entity 'Insights' named entity 'viral' named entity 'patients' named entity 'postmortem' named entity 'DAD' named entity 'cardiovascular disease' named entity 'exudative' named entity 'pneumonia' named entity 'pulmonary' named entity 'pneumonia' named entity 'pneumonia' named entity 'pathogenesis' named entity 'pneumonia' named entity 'endothelium' named entity 'mechanical ventilation' named entity 'type II diabetes mellitus' named entity 'IHC' named entity 'acute respiratory distress syndrome' named entity 'New York' named entity 'Pulmonary edema' named entity 'lymphoid' named entity 'antigen' named entity 'pneumocyte' named entity 'IHC' named entity 'lungs' named entity 'tissue sections' named entity 'DAD' named entity 'acute phase' named entity 'mechanical ventilation' named entity 'histologic' named entity 'immunoreactivity' named entity 'DAD' named entity 'DAD' named entity 'lung' named entity 'viral RNA' named entity 'IHC' named entity 'type II pneumocytes' named entity 'histology' named entity 'fatigue' named entity 'hyaline' named entity 'parenchyma' named entity 'postmortem' named entity 'SARS-CoV-2' named entity 'lungs' named entity 'IHC' named entity 'pathogenesis' named entity 'antibody' named entity 'COVID' named entity 'pneumonia' named entity 'histiocytes' named entity 'endothelial cells' named entity 'cough' named entity 'SARS-CoV-1' named entity 'respiratory failure' named entity 'asystolic' named entity 'DAD' named entity 'DAD' named entity 'DAD' named entity 'differential diagnosis' named entity 'SARS-CoV-2' named entity 'chromatin' named entity 'DAD' named entity 'postmortem' named entity 'nucleoprotein'

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