About: RNA sequence and secondary structural determinants in a minimal viral promoter that directs replicase recognition and initiation of genomic plus-strand RNA synthesis 1 1 Edited by D. E. Draper

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About: RNA sequence and secondary structural determinants in a minimal viral promoter that directs replicase recognition and initiation of genomic plus-strand RNA synthesis 1 1 Edited by D. E. Draper Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	RNA sequence and secondary structural determinants in a minimal viral promoter that directs replicase recognition and initiation of genomic plus-strand RNA synthesis 1 1 Edited by D. E. Draper
Creator	Kim, Chul-Hyun Cheng Kao, C Sivakumaran, K Tayon, Robert
Source	Elsevier; Medline; PMC
abstract	Abstract Viral RNA replication provides a useful system to study the structure and function of RNAs and the mechanism of RNA synthesis from RNA templates. Previously we demonstrated that a 27 nt RNA from brome mosaic virus (BMV) can direct correct initiation of genomic plus-strand RNA synthesis by the BMV replicase. In this study, using biochemical, nuclear magnetic resonance, and thermodynamic analyses, we determined that the secondary structure of this 27 nt RNA can be significantly altered and retain the ability to direct RNA synthesis. In contrast, we find that position-specific changes in the RNA sequence will affect replicase recognition, modulate the polymerization process, and contribute to the differential accumulation of viral RNAs. These functional results are in agreement with the phylogenetic analysis of BMV and related viral sequences and suggest that a similar mechanism of RNA synthesis takes place for members of the alphavirus superfamily.
has issue date	1999-12-03(xsd:dateTime)
bibo:doi	10.1006/jmbi.1999.3297
bibo:pmid	10610788
has license	els-covid
sha1sum (hex)	8a835eec68c335d412ed7af32a557373771bfd59
schema:url	https://doi.org/10.1006/jmbi.1999.3297
resource representing a document's title	RNA sequence and secondary structural determinants in a minimal viral promoter that directs replicase recognition and initiation of genomic plus-strand RNA synthesis 1 1 Edited by D. E. Draper
has PubMed Central identifier	PMC7172556
has PubMed identifier	10610788
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:8a835eec68c335d412ed7af32a557373771bfd59#body_text
is schema:about of	named entity 'RNAs' named entity 'Viral' named entity 'BMV' named entity 'RNA' named entity 'RNA' named entity 'nuclear magnetic resonance' named entity 'RNA' named entity 'Initiation' named entity 'PREVIOUSLY' named entity 'VIRAL' named entity 'INITIATION' named entity 'POLYMERIZATION' named entity 'SUGGEST' named entity 'ALPHAVIRUS' named entity 'DEMONSTRATED' named entity 'POSITION' named entity 'RNA SEQUENCE' named entity 'CONTRAST' named entity 'DIFFERENTIAL' named entity 'THESE' named entity 'retain' named entity 'RNA' named entity 'These' named entity 'affect' named entity 'viral RNAs' named entity 'RNA' named entity 'polymerization' named entity 'thermodynamic' named entity 'Secondary Structural' named entity 'Replicase' named entity 'BMV' named entity 'subgenomic' named entity 'minus-strand' named entity 'subgenomic' named entity 'RNA' named entity 'mutation' named entity 'RNA' named entity 'dicistronic' named entity 'minus-strand' named entity 'base-pair' named entity 'RNA synthesis' named entity 'Bruker' named entity 'nucleotides' named entity 'Bruker' named entity 'Bruker' named entity 'Electrophoresis' named entity 'BMV' named entity 'ethidium bromide' named entity 'RNAs' named entity 'RNA' named entity 'replicase' named entity 'cowpea chlorotic mottle virus' named entity 'RNA' named entity 'viral RNA' named entity 'genomic sequences' named entity 'nucleotides' named entity 'replicase' named entity 'RNAs' named entity 'EDTA' named entity 'nucleotides' named entity 'G/C' named entity 'polyacrylamide gels' named entity 'NMR spectra' named entity 'Sivakumaran' named entity 'replicase' named entity 'RNA synthesis' named entity 'denaturing' named entity 'BMV' named entity 'alphavirus' named entity 'wildtype' named entity 'RNA synthesis' named entity 'RNA synthesis' named entity 'native gel' named entity 'RNA synthesis' named entity 'stem-loop structures' named entity 'base-paired' named entity 'wild-type' named entity 'base-pairs'

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