About: The effect of immunosuppression on protective immunity of turkey poults against infection with turkey coronavirus

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About: The effect of immunosuppression on protective immunity of turkey poults against infection with turkey coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The effect of immunosuppression on protective immunity of turkey poults against infection with turkey coronavirus
Creator	Hooper, Tom Schrader, Donna Bryan, Thomas Chien, Chang Lin, Wu, Ching Loa, Tsang
Source	Elsevier; Medline; PMC
abstract	Abstract The objective of the present study was to evaluate the protective effect of humoral and cellular immunities on turkeys infected with turkey coronavirus (TCV). Two trials were conducted with two separate hatches of turkey poults. Turkeys were experimentally immunosuppressed with cyclosporin A (CsA) or cyclophosphamide (CY) and infected with TCV. Prior to infection, treatment with CsA selectively suppressed T cell activity as revealed by 2–3 fold decreased (p<0.1) lymphocyte proliferation responses to a T cell mitogen, concanavalin A (Con A). Treatment with CY mainly induced B cell deficiency as indicated by significant reductions (p<0.05) in antibody responses to sheep erythrocytes 7 days after injection. Body weight gain of turkeys treated with CY was significantly lower (p<0.05) than that of untreated turkeys at 9 days post-infection (PI). Turkeys treated with CY had 1–2 fold higher immunofluorescent antibody assay (IFA) scores for TCV antigens (p<0.05) in the intestine than untreated turkeys at 9 or 14 days PI. These results suggested that humoral immunity against TCV infection may be important in turkeys.
has issue date	2002-03-31(xsd:dateTime)
bibo:doi	10.1016/s0147-9571(01)00033-9
bibo:pmid	11848129
has license	els-covid
sha1sum (hex)	8a541d5535412574cecb9a7bf5489e569896d15c
schema:url	https://doi.org/10.1016/s0147-9571%2801%2900033-9
resource representing a document's title	The effect of immunosuppression on protective immunity of turkey poults against infection with turkey coronavirus
has PubMed Central identifier	PMC7134125
has PubMed identifier	11848129
schema:publication	Comparative Immunology, Microbiology and Infectious Diseases
resource representing a document's body	covid:8a541d5535412574cecb9a7bf5489e569896d15c#body_text
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