About: Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes

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About: Structural basis for the differential classification of HLA-A6802 and HLA-A6801 into the A2 and A3 supertypes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural basis for the differential classification of HLA-A6802 and HLA-A6801 into the A2 and A3 supertypes
Creator	Cheng, Hao Tan, Shuguang Qi, Jianxun Liu, Jun Zhang, Shihong Gao, George Niu, Ling Zhang, Yudan
Source	Elsevier; Medline; PMC
abstract	Abstract High polymorphism is one of the most important features of human leukocyte antigen (HLA) alleles, which were initially classified by serotyping but have recently been re-grouped into supertypes according to their peptide presentation properties. Two relatively prevalent HLA alleles HLA-A6801 and HLA-A6802, are classified into the same serotype HLA-A68. However, based on their distinct peptide-binding characteristics, HLA-A6801 is grouped into A3 supertype, whereas HLA-A6802 belongs to A2 supertype, similar to HLA-A0201. Thusfar, the structural basis of the different supertype definitions of these serotyping-identical HLA alleles remains largely unknown. Herein, we determined the structures of HLA-A6801 and HLA-A6802 presenting three typical A3 and A2 supertype-restricted peptides, respectively. The binding capabilities of these peptides to HLA-A6801, HLA-A6802, and HLA-A0201 were analyzed. These data indicate that the similar conformations of the residues within the F pocket contribute to close-related peptide binding features of HLA-A6802 and HLA-A0201. However, the overall structure and the peptide conformation of HLA-A6802 are more similar to HLA-A6801 rather than HLA-A0201 which illuminates the similar serotype grouping of HLA-A6802 and HLA-A*6801. Our findings are helpful for understanding the divergent peptide presentation and virus-specific CTL responses impacted by MHC micropolymorphisms and also elucidate the molecular basis of HLA supertype definitions.
has issue date	2013-10-31(xsd:dateTime)
bibo:doi	10.1016/j.molimm.2013.03.015
bibo:pmid	23566939
has license	els-covid
sha1sum (hex)	8a530622a9f6b79a586ebe790ac671a4cd23abed
schema:url	https://doi.org/10.1016/j.molimm.2013.03.015
resource representing a document's title	Structural basis for the differential classification of HLA-A6802 and HLA-A6801 into the A2 and A3 supertypes
has PubMed Central identifier	PMC7112617
has PubMed identifier	23566939
schema:publication	Molecular Immunology
resource representing a document's body	covid:8a530622a9f6b79a586ebe790ac671a4cd23abed#body_text
is schema:about of	named entity 'HLA-A' named entity 'CLASSIFICATION' named entity 'BASIS' named entity 'STRUCTURAL' named entity 'DIFFERENTIAL' named entity 'HLA-A' named entity 'HLA-A' named entity 'HLA-A' named entity 'peptide' named entity 'polymorphic' named entity 'HIV' named entity 'HLA-A' named entity 'HLA-A' named entity 'HLA-A' named entity 'salt bridge' named entity 'HLA-A' named entity 'epitopes' named entity 'mass spectrometry' named entity 'nitrogen' named entity 'hydrogen bonds' named entity 'HLA-A' named entity 'HLA-A' named entity 'peptide' named entity 'HLA-A' named entity 'peptides' named entity 'peptides' named entity 'HLA' named entity 'HLA-A' named entity 'HLA-A' named entity 'HLA-A' named entity 'HLA-A' named entity 'w/v' named entity 'crystallization' named entity 'root mean square deviation' named entity 'diffusion' named entity 'Peptides' named entity 'HLA-A' named entity 'aliphatic' named entity 'peptides' named entity 'protein' named entity 'peptide' named entity 'gel filtration chromatography' named entity 'HLA-A' named entity 'HLA-A' named entity 'HLA-A' named entity 'peptide' named entity 'HLA' named entity 'peptide' named entity 'aliphatic' named entity 'HLA-A' named entity 'HLA-A' named entity 'Asn' named entity 'amino acid' named entity 'Tyr' named entity 'HLA-A' named entity 'molecular replacement' named entity 'alleles' named entity 'HLA-A' named entity 'HLA-A' named entity 'helix' named entity 'polymorphic' named entity 'HLA-A' named entity 'alleles' named entity 'serological' named entity 'adaptive immune responses' named entity 'HLA-A' named entity 'HLA-A' named entity 'amino acids' named entity 'epitopes' named entity 'antigen presenting cells' named entity 'motif' named entity 'HLA-A' named entity 'HLA-A' named entity 'dimethyl sulfoxide'

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About: Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes Goto Sponge NotDistinct Permalink

About: Structural basis for the differential classification of HLA-A6802 and HLA-A6801 into the A2 and A3 supertypes Goto Sponge NotDistinct Permalink