About: A probable role for IFN-γ in the development of a lung immunopathology in SARS

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About: A probable role for IFN-γ in the development of a lung immunopathology in SARS Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A probable role for IFN-γ in the development of a lung immunopathology in SARS
Creator	Lei, Huan-Yao Liu, Ching-Chuan Chen, Yu-Wen Huang, Kao-Jean Theron, Michel
Source	Elsevier; Medline; PMC
abstract	Abstract Recent work carried out in our laboratory showed the existence of a cytokine storm in SARS patients, dominated by Th1-type mediators. We thus hypothesized that IFN-γ may play a major role in the pathology by triggering immune-mediated alveolar damage. As we assessed or re-assessed some effects of IFN-γ on a number of human lung epithelial and fibroblast cell lines, chosen for their wide use in the literature, we found that alveolar epithelial cells were more sensitive to IFN-γ, in terms of proliferation inhibition and enhancement of Fas-mediated apoptosis. While similar effects were obtained on fibroblasts, concentrations of IFN-γ 4–8-fold greater were required. In addition, both epithelial and fibroblastic cell lines were able to secrete large quantities of T cell-targeting chemokines, similar to the ones detected in SARS patients. Based on the clinical data collected previously, the available literature and our in vitro experimentation, we propose that IFN-γ may be responsible for acute lung injury in the late phase of the SARS pathology.
has issue date	2005-10-07(xsd:dateTime)
bibo:doi	10.1016/j.cyto.2005.07.007
bibo:pmid	16129616
has license	els-covid
sha1sum (hex)	8a51b2fd76dd37ff467598e0f5ed7dc76f9aacfa
schema:url	https://doi.org/10.1016/j.cyto.2005.07.007
resource representing a document's title	A probable role for IFN-γ in the development of a lung immunopathology in SARS
has PubMed Central identifier	PMC7129778
has PubMed identifier	16129616
schema:publication	Cytokine
resource representing a document's body	covid:8a51b2fd76dd37ff467598e0f5ed7dc76f9aacfa#body_text
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