About: Comparison of SARS-CoV-2 infections among 3 species of non-human primates

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparison of SARS-CoV-2 infections among 3 species of non-human primates
Creator	Ke, Changwen Li, Haiyan Yang, Jing Zhang, Yong Liu, Hongqi Yang, Yun Zheng, Huanying Peng, Xiaozhong Li, Jingmei Hu, Yunzhang Wang, Haixuan Dai, Qing Ding, Kaiyun Dong, Yinliang Gao, Jiahong Jiao, Li Kuang, Dexuan Lin, Xiaochen Liu, Yuqin Long, Haiting Luo, Fangyu Ma, Chunxia Qian, Xingli Wang, Junbin Wu, Daoju Xu, Jingwen Yang, Mengli Zhao, Yuan Zhao, Siwen Zhou, Jingxian Sun, Qiangmin Zheng, Yingqiu
Source	BioRxiv
abstract	COVID-19, caused by SARS-CoV-2 infection, has recently been announced as a pandemic all over the world. Plenty of diagnostic, preventive and therapeutic knowledges have been enriched from clinical studies since December 2019. However, animal models, particularly non-human primate models, are urgently needed for critical questions that could not be answered in clinical patients, evaluations of anti-viral drugs and vaccines. In this study, two families of non-human primates, Old world monkeys (12 Macaca mulatta, 6 Macaca fascicularis) and New world monkeys (6 Callithrix jacchus), were experimentally inoculated with SARS-CoV-2. Clinical signs were recorded. Samples were collected for analysis of viral shedding, viremia and histopathological examination. Increased body temperature was observed in 100% (12/12) M. mulatta, 33.3% (2/6) M. fascicularis and none (0/6) of C. jacchus post inoculation of SARS-CoV-2. All of M. mulatta and M. fascicularis showed chest radiographic abnormality. Viral genomes were detected in nasal swabs, throat swabs, anal swabs and blood from all 3 species of monkeys. Viral shedding from upper respiratory samples reached the peak between day 6 and day 8 post inoculation. From necropsied M. mulatta and M. fascicularis, the tissues showing virus positive were mainly lung, weasand, bronchus and spleen. No viral genome was seen in any of tissues from 2 necropsied C. jacchus. Severe gross lesions and histopathological changes were observed in lung, heart and stomach of SARS-CoV-2 infected animals. In summary, we have established a NHP model for COVID-19, which could be used to evaluate drugs and vaccines, and investigate viral pathogenesis. M. mulatta is the most susceptible to SARS-CoV-2 infection, followed by M. fascicularis and C. jacchus. One Sentence Summary M. mulatta is the most susceptible to SARS-CoV-2 infection as compared to M. fascicularis and C. jacchus.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1101/2020.04.08.031807
has license	biorxiv
sha1sum (hex)	8a1340eea275a67c97aaf9326f4045ee3b940960
schema:url	https://doi.org/10.1101/2020.04.08.031807
resource representing a document's title	Comparison of SARS-CoV-2 infections among 3 species of non-human primates
schema:publication	bioRxiv
resource representing a document's body	covid:8a1340eea275a67c97aaf9326f4045ee3b940960#body_text
is schema:about of	named entity 'viral shedding' named entity 'vaccines' named entity 'anti-viral' named entity 'swabs' named entity 'infections' named entity 'SARS-CoV-2' named entity 'inoculated' named entity 'lung' named entity 'experimentally' named entity 'needed' named entity 'therapeutic' named entity 'patients' named entity 'inoculation' named entity 'study' named entity 'genome' named entity 'anal' named entity 'monkeys' named entity 'Clinical' named entity 'Callithrix jacchus' named entity 'signs' named entity 'swabs' named entity 'bronchus' named entity 'histopathological examination' named entity 'Macaca fascicularis' named entity 'inoculation' named entity 'Viral shedding' named entity 'clinical studies' named entity 'viremia' named entity 'lung' named entity 'Callithrix jacchus' named entity 'species' named entity 'anti-viral drugs' named entity 'COVID' named entity 'Increased body temperature' named entity 'M. fascicularis' named entity 'non-human primates' named entity 'answered' named entity 'radiographic' named entity 'SARS-CoV-2' named entity 'virus' named entity 'spleen' named entity 'SARS-CoV-2' named entity 'M. fascicularis' named entity 'Viral genomes' named entity 'Macaca mulatta' covid:arg/8a1340eea275a67c97aaf9326f4045ee3b940960 named entity 'non-human primate' named entity 'vaccines' named entity 'SARS-CoV-2' named entity 'radiographic' named entity 'viral genome' named entity 'SARS-CoV-2' named entity 'animal models'

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