About: Proteomics Comparison of Cerebrospinal Fluid of Relapsing Remitting and Primary Progressive Multiple Sclerosis

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About: Proteomics Comparison of Cerebrospinal Fluid of Relapsing Remitting and Primary Progressive Multiple Sclerosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Proteomics Comparison of Cerebrospinal Fluid of Relapsing Remitting and Primary Progressive Multiple Sclerosis
Creator	Singh, Vaibhav Stingl, Christoph Burgers, Peter Dekker, Lennard Hintzen, Rogier Luider, Theo Sillevis Smitt, Peter Stoop, Marcel Titulaer, Mark
Source	PMC
abstract	BACKGROUND: Based on clinical representation of disease symptoms multiple sclerosis (MScl) patients can be divided into two major subtypes; relapsing remitting (RR) MScl (85–90%) and primary progressive (PP) MScl (10–15%). Proteomics analysis of cerebrospinal fluid (CSF) has detected a number of proteins that were elevated in MScl patients. Here we specifically aimed to differentiate between the PP and RR subtypes of MScl by comparing CSF proteins. METHODOLOGY/PRINCIPAL FINDINGS: CSF samples (n = 31) were handled according to the same protocol for quantitative mass spectrometry measurements we reported previously. In the comparison of PP MScl versus RR MScl we observed a number of differentially abundant proteins, such as protein jagged-1 and vitamin D-binding protein. Protein jagged-1 was over three times less abundant in PP MScl compared to RR MScl. Vitamin D-binding protein was only detected in the RR MScl samples. These two proteins were validated by independent techniques (western blot and ELISA) as differentially abundant in the comparison between both MScl types. CONCLUSIONS/SIGNIFICANCE: The main finding of this comparative study is the observation that the proteome profiles of CSF in PP and RR MScl patients overlap to a large extent. Still, a number of differences could be observed. Protein jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is suggested in literature that the Notch pathway is involved in the remyelination of MScl lesions. Aberration of normal homeostasis of Vitamin D, of which approximately 90% is bound to vitamin D-binding protein, has been widely implicated in MScl for some years now. Vitamin D directly and indirectly regulates the differentiation, activation of CD4+ T-lymphocytes and can prevent the development of autoimmune processes, and so it may be involved in neuroprotective elements in MScl.
has issue date	2010-08-27(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0012442
bibo:pmid	20805994
has license	cc-by
sha1sum (hex)	8a1127271041cb420bec9aa4be4afa5d62b2b3b7
schema:url	https://doi.org/10.1371/journal.pone.0012442
resource representing a document's title	Proteomics Comparison of Cerebrospinal Fluid of Relapsing Remitting and Primary Progressive Multiple Sclerosis
has PubMed Central identifier	PMC2929207
has PubMed identifier	20805994
schema:publication	PLoS One
resource representing a document's body	covid:8a1127271041cb420bec9aa4be4afa5d62b2b3b7#body_text
is schema:about of	named entity 'SYMPTOMS MULTIPLE' named entity 'PRIMARY' named entity 'BASED' named entity 'PROTEOMICS ANALYSIS' named entity 'REPRESENTATION' named entity 'PROTEINS' named entity 'PROGRESSIVE' named entity 'BACKGROUND' named entity 'MScl' named entity 'Cerebrospinal Fluid' named entity 'MAJOR' named entity 'SUBTYPES' named entity 'MULTIPLE SCLEROSIS' named entity 'RELAPSING' named entity 'MSCL' named entity 'DIFFERENTIATE' named entity 'CEREBROSPINAL FLUID' named entity 'RELAPSING' named entity 'CEREBROSPINAL FLUID' named entity 'REMITTING' named entity 'PROTEOMICS' named entity 'PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS' named entity 'DIVIDED' named entity 'ELEVATED' named entity 'COMPARING' named entity 'PATIENTS' named entity 'CSF' named entity 'NUMBER OF' named entity 'COMPARISON' named entity 'DETECTED' named entity '90%' named entity 'DISEASE' named entity 'REMITTING' named entity 'CLINICAL' named entity 'HERE' covid:arg/8a1127271041cb420bec9aa4be4afa5d62b2b3b7 named entity 'symptoms' named entity 'patients' named entity 'subtypes' named entity 'elevated' named entity 'Proteomics' named entity 'multiple sclerosis' named entity 'cerebrospinal fluid' named entity 'Proteomics' named entity 'relapsing remitting' named entity 'remyelination' named entity 'neurological disease' named entity 'univariate analysis' named entity 'diagnostic procedures' named entity 'T-cell' named entity 'calcium' named entity 'vitamin D-binding protein' named entity 'apolipoprotein A1' named entity 'p-value' named entity 'neurodegenerative diseases' named entity 'p-values' named entity 'vitamin' named entity 'plasma' named entity 'pathological processes' named entity 'apolipoprotein' named entity 'phenotype' named entity 'peptides' named entity 'neurodegenerative' named entity 'pathology' named entity 'protein' named entity 'peptides' named entity 'plasma' named entity 'non-significant' named entity '0.01' named entity 'Netherlands' named entity 'jagged-1' named entity 'oligoclonal bands' named entity 'jagged-1'

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