About: Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study
Creator	Freymuth, François Vabret, Astrid Charbonneau, Pierre Daubin, Cédric Parienti, Jean-Jacques Ramakers, Michel Vincent, Sophie Du Cheyron, Damien
source	Medline; PMC
abstract	INTRODUCTION: Respiratory viruses are a major cause of respiratory tract infections. The prevalence of a virus-positive respiratory sample and its significance in patients requiring mechanical ventilation remain unknown. METHODS: We conducted a cohort study in all consecutive adults ventilated for more than 48 hours admitted to a 22-bed medical intensive care unit during a 12-month period. Respiratory samples at the time of intubation were assessed by culture, by indirect immunofluorescence assay or by molecular methods in systematic tracheobronchial aspirates. Patients with a virus-negative respiratory sample at the time of intubation were considered unexposed and served as the control group. RESULTS: Forty-five viruses were isolated in 41/187 (22%) patients. Rhinovirus was the most commonly isolated virus (42%), followed byherpes simplex virus type 1 (22%) and virus influenza A (16%). In multivariate analysis controlling for the Acute Pathophysiology and Chronic Health Evaluation II score, patients with respiratory disorder at admission (adjusted odds ratio, 2.1; 95% confidence interval, 0.8–5.1; P = 0.12), with chronic obstructive pulmonary disease/asthma patients (adjusted odds ratio, 3.0; 95% confidence interval, 1.3–6.7; P = 0.01) and with admission between 21 November and 21 March (adjusted odds ratio, 2.8; 95% confidence interval, 1.3–5.9; P = 0.008) were independently associated with a virus-positive sample. Among the 122 patients admitted with respiratory disorder, a tracheobronchial aspirate positive for respiratory viruses at the time of intubation (adjusted hazard ratio, 0.273; 95% confidence interval, 0.096–0.777; P < 0.006) was independently associated with better survival, controlling for the Simplified Acute Physiology Score II and admission for cardiogenic shock or cardiac arrest. Among the remaining 65 patients, a virus-positive sample on intubation did not predict survival. CONCLUSION: We confirmed the pathogenic role of respiratory viruses in the intensive care unit, particularly rhinovirus. We suggest, however, that the prognostic value of virus-associated respiratory disorder is better than that of other causes of respiratory disorder.
has issue date	2006-10-05(xsd:dateTime)
bibo:doi	10.1186/cc5059
bibo:pmid	17022805
has license	cc-by
sha1sum (hex)	89eb2ddb11e00fa7652c170a84d919d2428d90f8
schema:url	https://doi.org/10.1186/cc5059
resource representing a document's title	Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study
has PubMed Central identifier	PMC1751045
has PubMed identifier	17022805
schema:publication	Crit Care
resource representing a document's body	covid:89eb2ddb11e00fa7652c170a84d919d2428d90f8#body_text
is schema:about of	named entity 'ACCESS' named entity 'CLINICAL' named entity 'VIRUS' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'POSITIVE' covid:arg/89eb2ddb11e00fa7652c170a84d919d2428d90f8 named entity 'OUTCOME' named entity 'PROSPECTIVE COHORT STUDY' named entity 'VENTILATED' named entity 'RESPIRATORY SAMPLES' named entity 'EPIDEMIOLOGY' named entity 'PATIENTS' named entity 'POSITIVE' named entity 'ITS' named entity 'RESPIRATORY SAMPLE' named entity 'INTRODUCTION' named entity 'A MAJOR' named entity 'RESPIRATORY VIRUSES' named entity 'MECHANICAL VENTILATION' named entity 'SIGNIFICANCE' named entity 'UNKNOWN' named entity 'PATIENTS' named entity 'CAUSE' named entity 'OPEN' named entity 'VIRUS' named entity 'PREVALENCE' named entity 'mechanical ventilation' named entity 'virus' named entity 'Open Access' named entity 'respiratory epithelium' named entity 'diabetes' named entity 'comorbidities' named entity 'virus' named entity 'rhinovirus' named entity 'viral infection' named entity 'virus' named entity 'virus' named entity 'risk factors' named entity 'cytomegalovirus' named entity 'rhinovirus' named entity 'Staphylococcus aureus' named entity 'aspirates' named entity 'interleukin' named entity 'viral infection' named entity 'RT-PCR' named entity 'influenza virus' named entity 'reverse transcriptase' named entity 'COPD' named entity 'experimental studies' named entity 'RNA' named entity 'probability' named entity 'viruses' named entity 'proinflammatory' named entity 'ICU' named entity 'viruses' named entity 'type 1' named entity 'Viruses' named entity 'diagnostic accuracy' named entity 'sputum production' named entity 'morbidity' named entity 'intubation' named entity 'nonparametric test' named entity 'Cox models' named entity 'ICU' named entity 'chi-square test' named entity 'epidemiology' named entity 'cardiogenic shock' named entity 'respiratory disorder' named entity 'Mann-Whitney' named entity 'respiratory disorder' named entity 'virus' named entity 'infectious agent' named entity 'Physiology' named entity 'Acute exacerbation'

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