About: scRNA-seq reveals ACE2 and TMPRSS2 expression in TROP2+ Liver Progenitor Cells: Implications in COVID-19 associated Liver Dysfunction

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About: scRNA-seq reveals ACE2 and TMPRSS2 expression in TROP2+ Liver Progenitor Cells: Implications in COVID-19 associated Liver Dysfunction Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	scRNA-seq reveals ACE2 and TMPRSS2 expression in TROP2+ Liver Progenitor Cells: Implications in COVID-19 associated Liver Dysfunction
Creator	Ginhoux, Florent Chow, Pierce Chan, Jerry Dasgupta, Ramanuj Goh, Brian Jia, Justine Kiat, Tony Lim, Hon Mishra, Archita Pai, Rhea Seow, Wen Sharma, Ankur Shepherdson, Edwin
source	BioRxiv
abstract	The recent pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 was first reported in China (December 2019) and now prevalent in ∼170 countries across the globe. Entry of SARS-CoV-2 into mammalian cells require the binding of viral Spike (S) proteins to the ACE2 (angiotensin converting enzyme 2) receptor. Once entered the S protein is primed by a specialised serine protease, TMPRSS2 (Transmembrane Serine Protease 2) in the host cell. Importantly, beside respiratory symptoms, consistent with other common respiratory virus infection when patients become viraemic, a significant number of COVID-19 patients also develop liver comorbidities. We explored if specific target cell-type in the mammalian liver, could be implicated in disease pathophysiology other than the general deleterious response to cytokine storms. Here we employed single-cell RNA-seq (scRNA-seq) to survey the human liver and identified potentially implicated liver cell-type for viral ingress. We report the co-expression of ACE2 and TMPRSS2 in a TROP2+ liver progenitor population. Importantly, we fail to detect the expression of ACE2 in hepatocyte or any other liver (immune and stromal) cell types. These results indicated that in COVID-19 associated liver dysfunction and cell death, viral infection of TROP2+ progenitors in liver may significantly impaired liver regeneration and could lead to pathology. Highlights - EPCAM+ Liver progenitors co-express ACE2 and TMPRSS2 - ACE2 and TMPRSS2 expression is highest in TROP2high progenitors - ACE2 and TMPRSS2 cells express cholangiocyte biased fate markers - ACE2 and TMPRSS2 positive cells are absent in human fetal liver
has issue date	2020-03-25(xsd:dateTime)
bibo:doi	10.1101/2020.03.23.002832
has license	biorxiv
sha1sum (hex)	89b0a7d066719cd6d1b45eae693a70a4045ccb5b
schema:url	https://doi.org/10.1101/2020.03.23.002832
resource representing a document's title	scRNA-seq reveals ACE2 and TMPRSS2 expression in TROP2+ Liver Progenitor Cells: Implications in COVID-19 associated Liver Dysfunction
schema:publication	bioRxiv
resource representing a document's body	covid:89b0a7d066719cd6d1b45eae693a70a4045ccb5b#body_text
is schema:about of	named entity 'cell' named entity 'respiratory' named entity 'common' named entity 'ACE2' named entity 'CONSISTENT WITH' named entity 'PROTEIN ' named entity 'S PROTEIN' named entity 'angiotensin' named entity 'Spike' named entity 'liver' named entity 'ACE2' named entity 'angiotensin converting enzyme 2' named entity 'ACE2' named entity 'Transmembrane' named entity 'liver cells' named entity 'cholangiocyte' named entity 'cholangiocytes' named entity 'written consent' named entity 'liver tissue' named entity 'SARS-CoV' named entity 'SARS-CoV-2' named entity 'ASGR1' named entity 'tissue samples' named entity 'zoonotic' named entity 'TACSTD2' named entity 'liver' named entity 'TMPRSS2' named entity 'Tissues' named entity 'hepatocellular carcinoma' named entity 'SARS-CoV-2' named entity 'hepatocellular carcinoma' named entity 'hepatocyte' named entity 'cholangiocyte' named entity 'SARS' named entity 'GI tract' named entity 'cholangiocyte' named entity 'SARS-CoV-2' named entity 'progenitor cells' named entity 'pathology' named entity 'cell types' named entity 'liver' named entity 'epithelial tissues' named entity 'epithelial' named entity 'alanine aminotransferase' named entity 'epithelial' named entity 'human liver' named entity 'cell type specific markers' named entity 'COVID' named entity 'liver' named entity 'GI tract' named entity 'cholangiocyte' named entity 'receptor' named entity 'mouse model' named entity 'liver' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2 pandemic' named entity 'airway' named entity 'human population' named entity 'human liver' named entity 'liver' named entity 'express genes' named entity 'ACE2' named entity 'ACE2' named entity 'vertical transmission' named entity 'pregnancy' named entity 'COVID-19' named entity 'human liver' named entity 'hepatocyte' named entity 'ACE2' named entity 'tumor' named entity 'ACE2'

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