About: Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: Mechanical ventilation during ECMO

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About: Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: Mechanical ventilation during ECMO Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: Mechanical ventilation during ECMO
Creator	Weber-Carstens, Steffen Welte, Tobias Pesenti, Antonio Costa, Eduardo Bein, Thomas Combes, Alain Schmidt, Matthieu Beutel, Gernot Quintel, Michael Brochard, Laurent Park, Marcelo Schultz, Marcus Slutsky, Arthur Ranieri, V Azevedo, Luciano Hodgson, Carol Gama De Abreu, Marcelo Lubnow, Matthias Neto, Ary Paiva, Jose-Artur Pelosi, Paolo Pham, Tài Takeda, Shinhiro Lueck, Catherina Lindskov, Christian Michaels, Andrew Ried, Michael Roncon-Albuquerque, Roberto Terragni, Pier Vejen, Marie
Source	PMC
abstract	PURPOSE: Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for patients with acute respiratory distress syndrome (ARDS). The aim of this study was to evaluate associations between ventilatory settings during ECMO for refractory hypoxemia and outcome in ARDS patients. METHODS: In this individual patient data meta-analysis of observational studies in adult ARDS patients receiving ECMO for refractory hypoxemia, a time-dependent frailty model was used to determine which ventilator settings in the first 3 days of ECMO had an independent association with in-hospital mortality. RESULTS: Nine studies including 545 patients were included. Initiation of ECMO was accompanied by significant decreases in tidal volume size, positive end-expiratory pressure (PEEP), plateau pressure, and driving pressure (plateau pressure − PEEP) levels, and respiratory rate and minute ventilation, and resulted in higher PaO(2)/FiO(2), higher arterial pH and lower PaCO(2) levels. Higher age, male gender and lower body mass index were independently associated with mortality. Driving pressure was the only ventilatory parameter during ECMO that showed an independent association with in-hospital mortality [adjusted HR, 1.06 (95 % CI, 1.03–1.10)]. CONCLUSION: In this series of ARDS patients receiving ECMO for refractory hypoxemia, driving pressure during ECMO was the only ventilator setting that showed an independent association with in-hospital mortality. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00134-016-4507-0) contains supplementary material, which is available to authorized users.
has issue date	2016-09-01(xsd:dateTime)
bibo:doi	10.1007/s00134-016-4507-0
bibo:pmid	27586996
has license	no-cc
sha1sum (hex)	89924e5b026b6b463e34a7021ec0f9ee9f4bce61
schema:url	https://doi.org/10.1007/s00134-016-4507-0
resource representing a document's title	Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: Mechanical ventilation during ECMO
has PubMed Central identifier	PMC7094949
has PubMed identifier	27586996
schema:publication	Intensive Care Med
resource representing a document's body	covid:89924e5b026b6b463e34a7021ec0f9ee9f4bce61#body_text
is schema:about of	named entity 'Associations' named entity 'Network' named entity 'Research' named entity 'data analysis' named entity 'REFRACTORY' named entity 'acute respiratory distress syndrome (ARDS)' named entity 'ARDS' named entity 'acute respiratory distress syndrome' named entity 'acute respiratory distress syndrome' named entity 'refractory' named entity 'hypoxemia' named entity 'rescue therapy' named entity 'refractory' named entity 'Pneumonia' named entity 'respiratory rates' named entity 'ECMO' named entity 'Windows' named entity 'respiratory rate' named entity 'alveolar' named entity 'ECMO' named entity 'ECMO' named entity 'Tidal volume' named entity 'ECMO' named entity 'statistical significance' named entity 'PEEP' named entity 'risk of death' named entity 'plateau pressure' named entity 'APACHE III' named entity 'risk of death' named entity 'mechanical ventilation' named entity 'hypoxemia' named entity 'ARDS' named entity 'tidal volume' named entity 'ARDS' named entity 'positive end-expiratory pressure' named entity 'multivariable analysis' named entity 'PEEP' named entity 'body mass index' named entity 'ICU' named entity 'blood flow' named entity 'analysis of variance' named entity 'reactive oxygen' named entity 'mediation analyses' named entity 'endothelial cell' named entity 'mechanical ventilation' named entity 'ECMO' named entity 'PEEP' named entity 'ECMO' named entity 'volutrauma' named entity 'ECMO' named entity 'chemical bonds' named entity 'IBM'

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