About: The case for Chronotherapy in COVID‐19 induced Acute Respiratory Distress Syndrome (ARDS).

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About: The case for Chronotherapy in COVID‐19 induced Acute Respiratory Distress Syndrome (ARDS). Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The case for Chronotherapy in COVID‐19 induced Acute Respiratory Distress Syndrome (ARDS).
Creator	Chen, Zheng Akkanti, Bindu Yoo, Seung-Hee Abusamak, Mohammad Harry, Karmouty, Quintana Karmouty-Quintana, Harry Tamimi, Faleh
Source	Medline; PMC
abstract	COVID‐19, the disease resulting from infection by a novel coronavirus: SARS‐Cov2 that has rapidly spread since November 2019 leading to a global pandemic. SARS‐Cov2 has infected over 4 million people and caused over 290,000 deaths worldwide. Although most cases are mild, a subset of patients develop a severe and atypical presentation of Acute Respiratory Distress Syndrome (ARDS) that is characterised by a cytokine release storm (CRS). Paradoxically, treatment with anti‐inflammatory agents and immune regulators has been associated with worsening of ARDS. We hypothesize that the intrinsic circadian clock of the lung and the immune system may regulate individual components of CRS and thus chronotherapy may be used to effectively manage ARDS in COVID‐19 patients.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.1111/bph.15140
bibo:pmid	32442317
has license	no-cc
sha1sum (hex)	896591650b7cd9bb68fe93a5463067ca68e61a59
schema:url	https://doi.org/10.1111/bph.15140
resource representing a document's title	The case for Chronotherapy in COVID‐19 induced Acute Respiratory Distress Syndrome (ARDS).
has PubMed Central identifier	PMC7280566
has PubMed identifier	32442317
schema:publication	Br J Pharmacol
resource representing a document's body	covid:896591650b7cd9bb68fe93a5463067ca68e61a59#body_text
is schema:about of	named entity 'CRS' named entity 'RESULTING FROM' named entity 'INFECTED' named entity 'MILLION' named entity 'atypical' named entity 'disease' named entity 'caused' named entity 'Acute Respiratory Distress Syndrome (ARDS)' named entity 'coronavirus' named entity 'SARS' named entity 'cytokine' named entity 'ARDS' named entity 'Bmal1' named entity 'norepinephrine' named entity 'influenza' named entity 'SNS' named entity 'circadian clock' named entity 'parainfluenza' named entity 'virus' named entity 'parainfluenza' named entity 'lungs' named entity 'inflammatory mediators' named entity 'Club cells' named entity 'viral load' named entity 'leukocyte' named entity 'COVID-19' named entity 'anti-inflammatory' named entity 'lung tissue' named entity 'anti-inflammatory drugs' named entity 'virus' named entity 'viral pneumonia' named entity 'ACTH' named entity 'viruses' named entity 'SARS' named entity 'inflammatory mediators' named entity 'gene' named entity 'cardiovascular complications' named entity 'bronchiolitis' named entity 'REV-ERBα' named entity 'interleukin' named entity 'Ehlers' named entity 'IAV' named entity 'ibuprofen' named entity 'lung inflammation' named entity 'adrenocorticotropic hormone' named entity 'pneumonia' named entity 'anti-viral' named entity 'ACTH' named entity 'Bmal1' named entity 'animal models' named entity 'asthma' named entity 'lung injury' named entity 'influenza' named entity 'Circadian rhythms' named entity 'immune response' named entity 'COVID-19' named entity 'lung' named entity 'VEGF' named entity 'therapeutic development' named entity 'drug administration' named entity 'G-CSF' named entity 'HPA' named entity 'IL-8' named entity 'ACTH' named entity 'circadian clock' named entity 'respiratory failure' named entity 'wild-type' named entity 'adrenal glands' named entity 'cortisol' named entity 'TLR9' named entity 'acute respiratory distress syndrome' named entity 'ARDS' named entity 'REV-ERBα' named entity 'circadian clock'

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