About: Possible Role of Histone H1 in the Regulation of Furin-dependent Proprotein Processing

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Possible Role of Histone H1 in the Regulation of Furin-dependent Proprotein Processing
Creator	Chi, Chengwu Han, Jinbo Gu, Jianxin
source	PMC
abstract	Histone H1 and its C-terminal lysine rich fragments were recently found to be potent inhibitors of furin, a mammalian proprotein convertase. However, its role in the regulation of furin-dependent proprotein processing remains unclear. Here we report that histone H1 efficiently blocks furin-dependent pro-von Willebrand factor (pro-vWF) processing in a dose-dependent manner. Coimmunoprecipitation and immunofluorescence studies confirmed that histone H1 could interact with furin, and the interaction mainly took place on the cell surface. We noted that histone H1 was released from cells undergoing necrosis and apoptosis induced by H(2)O(2). Our findings suggested that histone H1 might be involved in extracellular and/or intracellular furin regulation.
has issue date	2007-03-01(xsd:dateTime)
bibo:doi	10.1111/j.1745-7270.2007.00267.x
bibo:pmid	17342255
has license	no-cc
sha1sum (hex)	8949cbe6be6dc09b2b27440df10c91550e99e5c1
schema:url	https://doi.org/10.1111/j.1745-7270.2007.00267.x
resource representing a document's title	Possible Role of Histone H1 in the Regulation of Furin-dependent Proprotein Processing
has PubMed Central identifier	PMC7109942
has PubMed identifier	17342255
schema:publication	Acta Biochim Biophys Sin (Shanghai)
resource representing a document's body	covid:8949cbe6be6dc09b2b27440df10c91550e99e5c1#body_text
is schema:about of	named entity 'regulation' named entity 'furin' named entity 'surface' named entity 'regulation' named entity 'immunofluorescence' named entity 'proprotein convertase' named entity 'Possible' named entity 'apoptosis' named entity 'lysine' named entity 'von Willebrand factor' named entity 'necrosis' named entity 'furin' named entity 'histone H1' named entity 'Histone H1' named entity 'furin' named entity 'protein' named entity 'furin' named entity 'FITC' named entity 'furin' named entity 'histone H1' named entity 'transfection' named entity 'NaCl' named entity 'Serpin' named entity 'therapeutic target' named entity 'furin' named entity 'Dulbecco's modified Eagle's medium' named entity 'HeLa' named entity 'transfection' named entity 'immunoprecipitated' named entity 'vWF' named entity 'annexin' named entity 'fimbriae' named entity 'serum proteins' named entity 'histone H1' named entity 'histone H1' named entity 'cell death' named entity 'fetal bovine serum' named entity 'proprotein' named entity 'antimicrobial' named entity 'exotoxins' named entity 'BHK' named entity 'vWF' named entity 'primer' named entity 'fluorescent staining' named entity 'NaCl' named entity 'anticancer activity' named entity 'mAb' named entity 'histones' named entity 'pathological conditions' named entity 'NP-40' named entity 'vWF' named entity 'pulse labeling' named entity 'staining' named entity 'SDS-PAGE' named entity 'furin' named entity 'exotoxins' named entity 'proprotein' named entity 'cysteine-rich' named entity 'TGN' named entity 'furin' named entity 'furin' named entity 'dose-dependent manner' named entity 'cell surface' named entity 'incubation' named entity 'horseradish peroxidase' named entity 'nucleus' named entity 'hormone receptors' named entity 'cell plasma membrane' named entity 'nucleus' named entity 'necrosis' named entity 'cell death' named entity 'vWF' named entity 'apoptosis' named entity 'cloned' named entity 'physiological' named entity 'Invitrogen' named entity 'cell death' named entity 'isothiocyanate' named entity 'epithelial layer'

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