About: Homologous collagen‐induced arthritis in ratg and mice are associated with structurally different major histocompatibility complex DQ‐like molecules

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About: Homologous collagen‐induced arthritis in ratg and mice are associated with structurally different major histocompatibility complex DQ‐like molecules Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Homologous collagen‐induced arthritis in ratg and mice are associated with structurally different major histocompatibility complex DQ‐like molecules
Creator	Vingsboo, Carina Goldschmidto, Tom Gustafssono, Kenth Hedrich+, Hans Holmdahlo, Kikard Karlssono, Mikael Kvicko, Christina
source	PMC
abstract	Collagen‐induced arthritis (CIA) in rats, induced with homologous type II collagen (CII), is a genetically more restricted disease and has better resemblance to rheumatoid arthritis by its chronic disease course, than CIA induced with heterologous CII. The DA strain is highly susceptible to CIA induced with homologous CII, while the Lewis strain is resistant. (DAxLew)F(1) is susceptible and backcrossing to Lewis reveals a close, but not complete, association of both arthritis and CII responsiveness to the RT1(a) haplotype. Analyses of congenic strains on DA and Lewis backgrounds suggest that expression of a major histocompatibility complex class II B(a) molecule, encoded from the RT1B(a) locus, is associated with arthritis susceptibility and CII responsiveness. The second exons coding for the first domains of the α and β chains of both the RT1(a) and RT1(1) haplotypes were sequenced and the deduced amino acid sequences compared with the corresponding molecule associated with susceptibility to CIA in the mouse (H‐2 A(q)). The sequences of the respective alleles revealed no obvious structural homology explaining the extensive similarities in the development of chronic autoimmune arthritis. Instead, this finding implies that different trimolecular constituents (i.e. class II,T cell receptor, and CII peptides) may yield an antigen presentation event that is able to trigger a similar autoaggressiveness in the two rodent species.
has issue date	2005-11-17(xsd:dateTime)
bibo:doi	10.1002/eji.1830220220
bibo:pmid	1537378
has license	no-cc
sha1sum (hex)	8936065192a304b6c8ac8fd0b2e1bbe66327369a
schema:url	https://doi.org/10.1002/eji.1830220220
resource representing a document's title	Homologous collagen‐induced arthritis in ratg and mice are associated with structurally different major histocompatibility complex DQ‐like molecules
has PubMed Central identifier	PMC7163539
has PubMed identifier	1537378
schema:publication	Eur J Immunol
resource representing a document's body	covid:8936065192a304b6c8ac8fd0b2e1bbe66327369a#body_text
is schema:about of	named entity 'MHC' named entity 'CIA' named entity 'CII' named entity 'Lewis' named entity 'CIA' named entity 'COMPARED' covid:arg/8936065192a304b6c8ac8fd0b2e1bbe66327369a named entity 'exons' named entity 'arthritis' named entity 'molecule' named entity 'expression' named entity 'haplotypes' named entity 'revealed' named entity 'similarities' named entity 'CII' named entity 'backgrounds' named entity 'arthritis' named entity 'susceptibility' named entity 'haplotype' named entity 'coding' named entity 'locus' named entity 'CIA' named entity 'antigen presentation' named entity 'rodent' named entity 'CIA' named entity 'chronic disease' named entity 'structural homology' named entity 'haplotype' named entity 'backcrossing' named entity 'arthritis' named entity 'homologous' named entity 'LewlA' named entity 'molecule' named entity 'lupus' named entity 'autoreactive T cells' named entity 'arthritis' named entity 'haplotypes' named entity 'haplotypes' named entity 'LA3' named entity 'autoantibodies' named entity 'haplotype' named entity 'haplotypes' named entity 'arthritis' named entity 'immunization' named entity 'RT1' named entity 'etiology' named entity 'homologous' named entity 'molecule' named entity 'rat' named entity 'genetic association' named entity 'autoreactive T cells' named entity 'rat' named entity 'rat' named entity 'RT1' named entity 'CIA' named entity 'rat' named entity 'structural homology' named entity 'emulsified' named entity 'immunogenic' named entity 'homologous' named entity 'homologous' named entity 'continuity correction' named entity 'immune response' named entity 'rat' named entity 'ABS' named entity 'immunization' named entity 'mice' named entity 'haplotype' named entity 'homologous' named entity 'chronic arthritis' named entity 'antibody response' named entity 'CIA' named entity 'cell receptors' named entity 'structural motifs' named entity 'chronic arthritis'

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