About: Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation
Creator	Kim, D Kim, Y Kim, K Lee, D Yoon, C Jeng, Jingyueh Kao, Vivia Wu, Ming-Jiuan Wu, Pei-Shan Yang, Jeng-Jer Yen, Jui-Hung Kao, J.-J Ko, W Wu, J.-H Wu, P.-S
Source	Elsevier; Medline; PMC
abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown have anti-inflammatory properties and are popularly used as complementary and alternative medicine in Asia. AIM OF THE STUDY: To investigate the underlying molecular mechanism and active chemicals in the ethanol extracts of V. patula (VP) and L. chinensis (LC). MATERIALS AND METHODS: The inhibitory activities of VP and LC on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) and interleukin-6 (IL-6) production were investigated in RAW264.7 macrophages and BV2 microglia. Downregulation of pro-inflammatory genes and upregulation of Nrf2 (NF-E2 p45-related factor 2)-ARE (antioxidant response element) pathway were investigated using RT-Q-PCR and Western blotting. Direct antioxidant capacities were measured using free radical scavenging and Folin-Ciocalteu assays. The flavonoids and triterpenes in VP and LC were identified by HPLC-ESI-MS. RESULTS: VP and LC inhibited NO and IL-6 production and suppressed iNOS, IL-6, IL-1β and CCL2 gene expression. VP and LC were potent direct antioxidants and effective indirect antioxidants assayed by Nrf2 activation and induction of heme oxygenase (HO)-1, glutamate-cysteine ligase modifier subunit (GCLM) and NAD(P)H quinone oxidoreductase 1 (NQO1). Three flavonoids including apigenin (1), luteolin (2) and chryseriol (3), and one triterpene betulinic acid (4) were found in VP; while compounds 1-4 and oleanolic acid (5) were in LC. CONCLUSION: Anti-inflammatory and antioxidant activities of VP and LC may be in great part attributed to the identified Nrf2 activating compounds, which induce expression of Phase II enzymes and attenuate the upregulation of pro-inflammatory genes.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.1016/j.jep.2020.113155
bibo:pmid	32736054
has license	no-cc
sha1sum (hex)	88ef79f3fadaed70ec5cbb51a5ce0343fbdaa5a7
schema:url	https://doi.org/10.1016/j.jep.2020.113155
resource representing a document's title	Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation
has PubMed Central identifier	PMC7385944
has PubMed identifier	32736054
schema:publication	J Ethnopharmacol
resource representing a document's body	covid:88ef79f3fadaed70ec5cbb51a5ce0343fbdaa5a7#body_text
is schema:about of	named entity 'CHRYSERIOL' named entity 'WESTERN BLOTTING' named entity 'RESULTS' named entity 'OLEANOLIC ACID' named entity 'HEME OXYGENASE' named entity 'PHASE II ENZYMES' named entity 'IDENTIFIED' named entity 'ABSTRACT' named entity 'ETHANOL' named entity 'pro-inflammatory' named entity 'NQO1' named entity 'betulinic acid' named entity 'anti-inflammatory' named entity 'IL-1β' named entity 'Downregulation' named entity 'IL-6' named entity 'macrophages' named entity 'Folin-Ciocalteu' named entity 'Nrf2' named entity 'Journal of Ethnopharmacology' named entity 'Nrf2' named entity 'response element' named entity 'upregulation' named entity 'Asia' named entity 'oxidoreductase' named entity 'antioxidant activities' named entity 'CCL2' named entity 'factor 2' named entity 'lipopolysaccharide' named entity 'bilirubin' named entity 'ethanol' named entity 'macrophage' named entity 'folk medicine' named entity 'HO-1' named entity 'phytochemicals' named entity 'iNOS' named entity 'cytotoxicity' named entity 'caffeic acid' named entity 'anti-inflammatory' named entity 'methanol' named entity 'SDS-PAGE' named entity 'IL-1β' named entity 'hydrogen' named entity 'TEAC' named entity 'anti-inflammatory' named entity 'protocatechuic acid' named entity 'primary antibody' named entity 'streptomycin' named entity 'anti-inflammatory' named entity 'GCL' named entity 'mass spectrometry' named entity 'Keap1' named entity 'anti-inflammatory' named entity 'Trolox' named entity 'mRNA' named entity 'rotary evaporator' named entity 'Heme oxygenase' named entity 'pro-inflammatory cytokines' named entity 'protein expression' named entity 'triterpenoid' named entity 'Taiwan' named entity 'dicaffeoylquinic acid' named entity 'Shimadzu' named entity 'iNOS' named entity 'Carbon monoxide' named entity 'flavonoids' named entity 'ng/mL'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software