About: Frailty Predicts Morbidity and Mortality After Laparoscopic Cholecystectomy for Acute Cholecystitis: An ACS-NSQIP Cohort Analysis

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About: Frailty Predicts Morbidity and Mortality After Laparoscopic Cholecystectomy for Acute Cholecystitis: An ACS-NSQIP Cohort Analysis Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Frailty Predicts Morbidity and Mortality After Laparoscopic Cholecystectomy for Acute Cholecystitis: An ACS-NSQIP Cohort Analysis
Creator	Di, Antonio Fagenson, Alexander Karachristos, Andreas Karhadkar, Sunil Lau, Kwan Powers, Benjamin Zorbas, Konstantinos
source	PMC
abstract	BACKGROUND: Current guidelines recommend laparoscopic cholecystectomy be offered for patients with acute cholecystitis except those deemed as high risk. Few studies have examined the impact of frailty on outcomes for patients undergoing laparoscopic cholecystectomy. Therefore, the aim of this study was to determine the association of frailty with postoperative morbidity and mortality in patients undergoing laparoscopic cholecystectomy for acute cholecystitis. METHODS: Patients undergoing laparoscopic cholecystectomy for acute cholecystectomy were identified from 2005 to 2010 in the American College of Surgeons National Surgical Quality Improvement Project (NSQIP). The Modified Frailty Index (mFI) was used a surrogate for frailty, and patients were stratified as non-frail (mFI 0), low frailty (mFI 1–2), intermediate frailty (mFI 3–4) and high frailty (mFI ≥ 5). Univariable and multivariable analyses were performed. Receiver operator curves (ROC) and an area under the curve (AUC) were generated to determine accuracy of mFI in predicting postoperative morbidity and mortality. RESULTS: Of the 6898 patients undergoing laparoscopic cholecystectomy, 3245 (47%) patients were non-frail. There were 2913 (42%) patients with low-frailty, 649 (9%) patients with intermediate frailty, and 91 (2%) with high frailty. Clavien IV complications were higher for intermediate frail patients (OR 1.81, 95% CI 1.00–3.28, p = 0.050) and high-frail patients (OR 4.59, 95% CI 1.98–10.7, p < 0.001). Additionally, mortality was higher for patients with intermediate frailty (OR 4.69, 95% CI 1.37–16.0, p = 0.014) and high frailty (OR 12.2, 95% CI 2.67–55.5, p = 0.001). The mFI had excellent accuracy for mortality (AUC = 0.83) and Clavien IV complications (AUC = 0.73). CONCLUSION: Frailty is associated with postoperative morbidity and mortality in patients undergoing laparoscopic cholecystectomy for acute cholecystitis.
has issue date	2020-03-24(xsd:dateTime)
bibo:doi	10.1007/s11605-020-04570-1
bibo:pmid	32212087
has license	no-cc
sha1sum (hex)	882c531d4f37cb8623df64d75763cb85153e42d9
schema:url	https://doi.org/10.1007/s11605-020-04570-1
resource representing a document's title	Frailty Predicts Morbidity and Mortality After Laparoscopic Cholecystectomy for Acute Cholecystitis: An ACS-NSQIP Cohort Analysis
has PubMed Central identifier	PMC7222970
has PubMed identifier	32212087
schema:publication	J Gastrointest Surg
resource representing a document's body	covid:882c531d4f37cb8623df64d75763cb85153e42d9#body_text
is schema:about of	named entity 'patients' named entity 'frailty' named entity 'patients' named entity 'patients' named entity 'mortality' named entity 'higher' named entity 'Receiver' named entity 'Cohort' named entity 'PREDICTING' named entity 'RESULTS' named entity 'STUDIES' named entity 'GUIDELINES ' named entity 'OPERATOR' named entity 'frailty' named entity 'morbidity' named entity 'ROC' named entity 'area' named entity 'higher' named entity 'AUC' named entity 'mFI' named entity 'mortality' named entity 'studies' named entity 'Background' named entity 'mFI' named entity 'multivariable' named entity 'frailty' named entity 'predicting' named entity 'Project' named entity 'acute cholecystitis' named entity 'laparoscopic cholecystectomy' named entity 'laparoscopic cholecystectomy' named entity 'morbidity' named entity 'area under the curve' named entity '10.7' named entity 'morbidity' named entity 'ACS' named entity 'cholecystectomy' named entity 'SSI' named entity 'morbidity' named entity 'comorbidities' named entity 'chronic obstructive pulmonary disease' named entity 'area under the curve' named entity 'percutaneous coronary angioplasty' named entity 'morbidity' named entity 'retrospective cohort study' named entity 'Chronic Health' named entity 'major surgery' named entity 'dialysis' named entity 'Bilirubin' named entity 'deep venous thrombosis' named entity 'normal distribution' named entity 'APACHE II' named entity 'ACS' named entity '20%' named entity 'surgical site infection' named entity 'laparoscopic cholecystectomy' named entity 'alternative treatment' named entity 'organ' named entity 'cardiac arrest' named entity 'morbidity' named entity 'Albumin' named entity 'cardiac surgery' named entity 'frailty' named entity 'surgical site infection' named entity 'septic shock' named entity 'peripheral vascular disease' named entity 'intensive care unit' named entity 'laparoscopic cholecystectomy' named entity '2.25' named entity 'morbidity' named entity 'neurological dysfunction' named entity 'NSQIP' named entity 'regression analysis' named entity 'multiorgan dysfunction' named entity 'pulmonary embolism'

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