About: Genetic recombination between RNA components of a multipartite plant virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic recombination between RNA components of a multipartite plant virus
Creator	Sobel, R Immun, Walker, M Przybyla, A Rutter, W Barr, P Bhan, A Blanchette, B Boulet, A Chirgwin, J Colvin, R Cordell, B Edlund, T Kostianovsky, M Lacy, P Lally, P Macdonald, R
Source	Medline; PMC
abstract	Genetic recombination of DNA is one of the fundamental mechanisms underlying the evolution of DNA-based organisms and results in their diversity and adaptability. The importance of the role of recombination is far less evident for the RNA-based genomes that occur in most plant viruses and in many animal viruses. RNA recombination has been shown to promote the evolutionary variation of picornaviruses(1–4), it is involved in the creation of defective interfering (DI) RNAs of positive- and negative-strand viruses(5–9) and is implicated in the synthesis of the messenger RNAs of influenza virus(10) and coronavirus(11). However, RNA recombination has not been found to date in viruses that infect plants. In fact, the lack of DI RNAs and the inability to demonstrate recombination in mixedly infected plants has been regarded as evidence that plants do not support recombination of viral RNAs. Here we provide the first molecular evidence for recombination of plant viral RNA. For brome mosaic virus (BMV), a plus-stranded, tripartite-genome virus of monocots, we show that a deletion in the 3′ end region of a single BMV RNA genomic component can be repaired during the development of infection by recombination with the homologous region of either of the two remaining wild-type BMV RNA components. This result clearly shows that plant viruses have available powerful recombinatory mechanisms that previously were thought to exist only in animal hosts, thus they are able to adapt and diversify in a manner comparable to animal viruses. Moreover, our observation suggests an increased versatility of viruses for use as vectors in introducing new genes into plants.
has issue date	1986-01-01(xsd:dateTime)
bibo:doi	10.1038/321528a0
bibo:pmid	2423879
has license	no-cc
sha1sum (hex)	880f042ae205dad2c31cfc5b6366cb626036191c
schema:url	https://doi.org/10.1038/321528a0
resource representing a document's title	Genetic recombination between RNA components of a multipartite plant virus
has PubMed Central identifier	PMC7095370
has PubMed identifier	2423879
schema:publication	Nature
resource representing a document's body	covid:880f042ae205dad2c31cfc5b6366cb626036191c#body_text
is schema:about of	named entity 'MODULATED' named entity '50%' named entity 'transgenic' named entity 'intravenous' named entity 'serum glucose levels' named entity 'nucleotides' named entity 'viruses' named entity 'mice' named entity 'fusion genes' named entity 'cDNA clone' named entity 'nucleotides' named entity 'antigen' named entity 'insulin' named entity 'organism' named entity 'mRNA' named entity 'evolution' named entity 'tolbutamide' named entity 'insulinoma' named entity 'stem-and-loop' named entity 'sweet-tasting' named entity 'glucose levels' named entity 'transgenic' named entity 'protein' named entity 'cDNA clone' named entity 'infection' named entity 'viral RNA' named entity 'coding region' named entity 'tolbutamide' named entity 'RNAs' named entity 're-ligation' named entity 'nuclease' named entity 'transgenic' named entity 'RNAs' named entity 'C-peptide' named entity 'wild-type' named entity 'BMV' named entity 'gene' named entity 'serum' named entity 'protein' named entity 'virus infection' named entity 'transgenic animals' named entity 'recombination' named entity 'Serum' named entity 'viral RNAs' named entity 'transgenic mice' named entity 'viruses' named entity 'tRNA' named entity 'human insulin' named entity 'polypeptides' named entity 'recombination' named entity 'proximal' named entity 'NIH' named entity 'amino acids' named entity 'fusion genes' named entity 'homologous' named entity 'nucleotide sequence' named entity 'selective advantage' named entity 'inoculation' named entity 'BMV' named entity 'gene expression' named entity 'gel electrophoresis' named entity 'nucleotides' named entity 'BMV' named entity 'blood glucose levels' named entity 'molecular evidence'

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