About: Biosafety Level 3 Laboratory for Autopsies of Patients with Severe Acute Respiratory Syndrome: Principles, Practices, and Prospects

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About: Biosafety Level 3 Laboratory for Autopsies of Patients with Severe Acute Respiratory Syndrome: Principles, Practices, and Prospects Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Biosafety Level 3 Laboratory for Autopsies of Patients with Severe Acute Respiratory Syndrome: Principles, Practices, and Prospects
Creator	Gong, Encong Gu, Jiang Li, Xingwang Shao, Hongquan Li, Ling Wang, Hao Shi, Xiaohong Cheng, Daiyun Gao, Xiaoqiang Guo, Lizhu Jiang, Huijun Shen, Bing Shi, Xicheng Shi, Xueying Wang, Peizhi Zhang, Qianying
Source	Medline; PMC
abstract	Background. During the outbreak of the emergent severe acute respiratory syndrome (SARS) infection, >30% of the ∼8000 infected persons were health care workers. The highly infectious nature of SARS coronavirus (SARS-CoV) compelled our pathologists to consider biosafety issues in the autopsy room and for tissue processing procedures. Methods. A specially designed biosafety level 3 (BSL-3) autopsy laboratory was constructed and divided into a clean area, a semicontaminated area, a contaminated area, and 2 buffer zones. High-efficiency particulate air filters were placed in the air supply and exhaust systems. Laminar air flow was from the clean areas to the less clean areas. The negative pressures of the contaminated, semicontaminated, and clean areas were approximately -50 pa, -25 pa, and -5 pa, respectively. Personal protective equipment, including gas mask, impermeable protective clothing, and 3 layers of gloves worn during autopsies; the equipment was decontaminated before it was allowed to exit the facility. Strict BSL-3 practices were followed. Results. When a given concentration of particulate sarin simulant was introduced into the contaminated area, it could not be detected in either the semicontaminated area or clean area, and particles >0.3 μm in size were not detected in the exhaust air. A total of 16 complete postmortem examinations for probable and suspected SARS were performed during a 2-month period. Of these, 7 reported confirmed cases of SARS. None of the 23 pathologists and technicians who participated in these autopsies was infected with SARS-CoV. Conclusions. Our experience suggests that BSL-3 laboratory operating principles should be among the special requirements for performing autopsies of contaminated bodies and that they can safeguard the clinicians and the environment involved in these procedures.
has issue date	2005-09-15(xsd:dateTime)
bibo:doi	10.1086/432720
bibo:pmid	16107979
has license	no-cc
sha1sum (hex)	880b4d0f9daaba79d6e848c8df40e0cd373471d1
schema:url	https://doi.org/10.1086/432720
resource representing a document's title	Biosafety Level 3 Laboratory for Autopsies of Patients with Severe Acute Respiratory Syndrome: Principles, Practices, and Prospects
has PubMed Central identifier	PMC7107885
has PubMed identifier	16107979
schema:publication	Clin Infect Dis
resource representing a document's body	covid:880b4d0f9daaba79d6e848c8df40e0cd373471d1#body_text
is schema:about of	named entity 'autopsy' named entity 'highly' named entity 'Biosafety Level 3' named entity 'PERSONS' named entity 'WORKERS' named entity 'HIGHLY' named entity 'INFECTION' named entity 'LABORATORY' covid:arg/880b4d0f9daaba79d6e848c8df40e0cd373471d1 named entity 'TISSUE PROCESSING' named entity 'AUTOPSIES' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'BIOSAFETY LEVEL 3' named entity 'PRACTICES' named entity 'BIOSAFETY' named entity 'HEALTH CARE' named entity 'PATHOLOGISTS' named entity 'AUTOPSY' named entity 'OUTBREAK' named entity 'OUR' named entity 'PATIENTS' named entity 'NATURE' named entity 'EMERGENT' named entity 'INFECTED' named entity 'INFECTIOUS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'ROOM' named entity 'ISSUES' named entity '130' named entity 'CONSIDER' named entity 'SARS CORONAVIRUS' named entity 'PROCEDURES' named entity 'SARS-CoV' named entity 'emergent' named entity 'compelled' named entity 'SARS-CoV' named entity 'Severe Acute Respiratory Syndrome' named entity 'Autopsies' named entity 'Solid waste' named entity 'Center for Disease Control' named entity 'China' named entity 'SARS' named entity 'gas masks' named entity 'autopsy' named entity 'autopsies' named entity 'Guangdong Province' named entity 'mortuary' named entity 'autopsy' named entity 'SARS' named entity 'Negative pressures' named entity 'peracetic acid' named entity 'chlorine' named entity 'SARS-CoV' named entity 'BSL-3' named entity 'sweat glands' named entity 'electrically neutral' named entity 'infectious diseases' named entity 'PPE' named entity 'air leakage' named entity 'autopsy' named entity 'BSL 3' named entity 'buffer zone' named entity 'autopsy' named entity 'pathogen' named entity 'aerosols' named entity 'formaldehyde'

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