About: New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1

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About: New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis
Creator	Castro, Carlos Ferreira, Anderson Fraga-Silva, Rodrigo Murça, Tatiane Raizada, Mohan Santos, Robson
Source	PMC
abstract	Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of the renin-angiotensin system (RAS). The discovery of the angiotensin-converting enzyme homologue ACE2 revealed important metabolic pathways involved in the Ang-(1–7) synthesis. This enzyme can form Ang-(1–7) from Ang II or less efficiently through hydrolysis of Ang I to Ang-(1–9) with subsequent Ang-(1–7) formation. Additionally, it is well established that the G protein-coupled receptor Mas is a functional ligand site for Ang-(1–7). The axis formed by ACE2/Ang-(1–7)/Mas represents an endogenous counter regulatory pathway within the RAS whose actions are opposite to the vasoconstrictor/proliferative arm of the RAS constituted by ACE/Ang II/AT(1) receptor. In this review we will discuss recent findings concerning the biological role of the ACE2/Ang-(1–7)/Mas arm in the cardiovascular and pulmonary system. Also, we will highlight the initiatives to develop potential therapeutic strategies based on this axis.
has issue date	2012-01-26(xsd:dateTime)
bibo:doi	10.1155/2012/147825
bibo:pmid	22319643
has license	cc-by
sha1sum (hex)	880b3f24a1f3678dd29cb446dae24298863b8676
schema:url	https://doi.org/10.1155/2012/147825
resource representing a document's title	New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis
has PubMed Central identifier	PMC3272817
has PubMed identifier	22319643
schema:publication	Int J Hypertens
resource representing a document's body	covid:880b3f24a1f3678dd29cb446dae24298863b8676#body_text
is schema:about of	named entity 'RECEPTOR' named entity 'This' named entity 'efficiently' named entity 'arm' named entity 'The' named entity 'Receptor' named entity 'AXIS' named entity 'FORMED' named entity 'ACTIONS' named entity 'ARM' named entity 'SYNTHESIS' named entity 'HYDROLYSIS' named entity 'MAS' named entity 'PULMONARY SYSTEM' named entity 'ANG' named entity 'ACE' named entity 'REGULATORY PATHWAY' named entity 'REVIEW' named entity 'OPPOSITE' named entity 'ANG II' named entity 'G PROTEIN-COUPLED RECEPTOR' named entity 'METABOLIC PATHWAYS' named entity 'RAS' named entity 'ANG I' named entity 'ANGIOTENSIN-CONVERTING ENZYME' named entity 'ENDOGENOUS' named entity 'COUNTER' named entity 'INVOLVED' named entity 'ESTABLISHED' named entity 'RECENT' named entity 'SUBSEQUENT' named entity 'DISCOVERY' named entity 'BASED' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'NEW' named entity 'BIOLOGICALLY' named entity 'FORM' named entity 'ANGIOTENSIN' named entity 'ACTIVE' named entity 'FUNCTIONAL' named entity 'HOMOLOGUE' named entity 'BIOLOGICAL ROLE' named entity 'FINDINGS' named entity 'ENZYME' named entity 'ACE2' named entity 'RECEPTOR' named entity 'THERAPEUTIC' named entity 'CARDIOVASCULAR AND PULMONARY' named entity 'STRATEGIES' named entity 'IMPORTANT' named entity 'COMPONENT' named entity 'VASOCONSTRICTOR' named entity 'DISCUSS' named entity 'STRATEGIES' named entity 'THERAPEUTIC' named entity 'IS A' named entity 'FORMATION' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'POTENTIAL' named entity 'REVEALED' named entity 'CARDIOVASCULAR AND PULMONARY' named entity 'SITE' named entity 'BASED' named entity 'INITIATIVES' named entity 'LIGAND' named entity 'AXIS' named entity 'receptor' named entity 'ANG' named entity 'potential' named entity 'revealed' named entity 'axis' named entity 'ligand' named entity 'involved' named entity 'regulatory pathway' named entity 'ANG' named entity 'initiatives'

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