About: The immune response to influenza in older humans: beyond immune senescence

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The immune response to influenza in older humans: beyond immune senescence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The immune response to influenza in older humans: beyond immune senescence
Creator	Haynes, Laura Pawelec, Graham Andrew, Melissa Mcelhaney, Janet Kuchel, George Verschoor, Chris
Source	PMC
abstract	Despite widespread influenza vaccination programs, influenza remains a major cause of morbidity and mortality in older adults. Age-related changes in multiple aspects of the adaptive immune response to influenza have been well-documented including a decline in antibody responses to influenza vaccination and changes in the cell-mediated response associated with immune senescence. This review will focus on T cell responses to influenza and influenza vaccination in older adults, and how increasing frailty or coexistence of multiple (≥2) chronic conditions contributes to the loss of vaccine effectiveness for the prevention of hospitalization. Further, dysregulation of the production of pro- and anti-inflammatory mediators contributes to a decline in the generation of an effective CD8 T cell response needed to clear influenza virus from the lungs. Current influenza vaccines provide only a weak stimulus to this arm of the adaptive immune response and rely on re-stimulation of CD8 T cell memory related to prior exposure to influenza virus. Efforts to improve vaccine effectiveness in older adults will be fruitless until CD8 responses take center stage.
has issue date	2020-05-07(xsd:dateTime)
bibo:doi	10.1186/s12979-020-00181-1
bibo:pmid	32399058
has license	cc-by
sha1sum (hex)	87f70527afcdab4b28790be00d63e2102c2747d8
schema:url	https://doi.org/10.1186/s12979-020-00181-1
resource representing a document's title	The immune response to influenza in older humans: beyond immune senescence
has PubMed Central identifier	PMC7204009
has PubMed identifier	32399058
schema:publication	Immun Ageing
resource representing a document's body	covid:87f70527afcdab4b28790be00d63e2102c2747d8#body_text
is schema:about of	named entity 'older adults' named entity 'responses' named entity 'generation' named entity 'MULTIPLE' named entity 'HOW' named entity 'INFLUENZA VACCINES' named entity 'ANTI-INFLAMMATORY' named entity 'DOCUMENTED' named entity 'CLEAR' named entity 'INFLUENZA' named entity 'mediators' named entity 'vaccine effectiveness' named entity 'mortality' named entity 'vaccine effectiveness' named entity 'influenza vaccine' named entity 'senescence' named entity 'neuraminidase' named entity 'death rates' named entity 'influenza infection' named entity 'antibody' named entity 'monocytes' named entity 'age-related' named entity 'immune responses' named entity 'Older adults' named entity 'mice' named entity 'vaccine' named entity 'virus' named entity 'influenza' named entity 'influenza' named entity 'lungs' named entity 'antibody' named entity 'production' named entity 'virus' named entity 'influenza vaccination' named entity 'influenza virus' named entity 'adaptive immune response' named entity 'influenza vaccination' named entity 'Age-related' named entity 'CD8 T cell' named entity 'CD8 T cell' named entity 'morbidity' named entity 'vaccine effectiveness' named entity 'hospitalization' named entity 'influenza vaccination' named entity 'influenza' named entity 'monocytes' named entity 'innate immune cells' named entity 'seasonal influenza' named entity 'influenza vaccines' named entity 'lung' named entity 'hemagglutination inhibition' named entity 'secretion' named entity 'pneumonia' named entity 'infection' named entity 'IL-6' named entity 'influenza' named entity 'vaccine adjuvants' named entity 'influenza vaccination' named entity 'weight loss' named entity 'bone marrow' named entity 'older adults' named entity 'PBMC' named entity 'vaccination rates' named entity 'older adults' named entity 'pneumonia' named entity 'Cardiovascular events' named entity 'influenza infection' named entity 'antigenic drift' named entity 'A/H3N2' named entity 'pDC' named entity 'vaccine efficacy' named entity 'terminally differentiated' named entity 'agonist' named entity 'influenza vaccine' named entity 'virus' named entity 'Singapore'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software