About: The role of chemokines and chemokine receptors in multiple sclerosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The role of chemokines and chemokine receptors in multiple sclerosis
Creator	Chen, Nai-Hong Chu, Shi-Feng Cui, Li-Yuan
Source	Elsevier; Medline; PMC
abstract	Abstract Multiple sclerosis (MS) is a chronic inflammatory disease that is characterized by leukocyte infiltration and subsequent axonal damage, demyelinating inflammation, and formation of sclerosing plaques in brain tissue. The results of various studies in patients indicate that autoimmunity and inflammation make an important impact on the pathogenesis of MS. Chemokines are key mediators of inflammation development and cell migration, mediating various immune cell responses, including chemotaxis and immune activation, and are important in immunity and inflammation, therefore we focus on chemokines and their receptors in multiple sclerosis. In this article, we summarize the study of the role of prominent chemokines and their receptors in MS patients and MS animal modelsand discuss their potential significance in inflammatory injury and repair of MS. We have also summarized the progress in the treatment of multiple sclerosis antagonists in recent years with chemokine receptors as targets.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1016/j.intimp.2020.106314
bibo:pmid	32197226
has license	els-covid
sha1sum (hex)	87dc0d35c4813a03c19333d1325088382f0dc536
schema:url	https://doi.org/10.1016/j.intimp.2020.106314
resource representing a document's title	The role of chemokines and chemokine receptors in multiple sclerosis
has PubMed Central identifier	PMC7156228
has PubMed identifier	32197226
schema:publication	International Immunopharmacology
resource representing a document's body	covid:87dc0d35c4813a03c19333d1325088382f0dc536#body_text
is schema:about of	named entity 'patients' named entity 'key' named entity 'chemokines' named entity 'development' named entity 'chemokines' named entity 'FOCUS' named entity 'BRAIN TISSUE' named entity 'RECEPTORS' named entity 'HAVE' named entity 'REPAIR' named entity 'DEVELOPMENT' named entity 'LEUKOCYTE INFILTRATION' named entity 'IS A' named entity 'YEARS' named entity 'RECENT' named entity 'IMPORTANT' named entity 'TARGETS' named entity 'MULTIPLE SCLEROSIS' named entity 'PROGRESS' named entity 'TREATMENT' named entity 'CELL MIGRATION' covid:arg/87dc0d35c4813a03c19333d1325088382f0dc536 named entity 'PLAQUES' named entity 'STUDY' named entity 'SUBSEQUENT' named entity 'DISCUSS' named entity 'MEDIATING' named entity 'AUTOIMMUNITY' named entity 'ROLE' named entity 'CHEMOKINES' named entity 'MULTIPLE SCLEROSIS' named entity 'CHEMOKINE RECEPTORS' named entity 'PATIENTS' named entity 'CHRONIC INFLAMMATORY DISEASE' named entity 'CHARACTERIZED' named entity 'IMMUNITY' named entity 'IMPACT' named entity 'ROLE' named entity 'INCLUDING' named entity 'POTENTIAL' named entity 'CHEMOKINES' named entity 'PATHOGENESIS' named entity 'CHEMOTAXIS' named entity 'INJURY' named entity 'RESPONSES' named entity 'ARTICLE' named entity 'THEIR' named entity 'INFLAMMATORY' named entity 'ANTAGONISTS' named entity 'PROMINENT' named entity 'ANIMAL' named entity 'MS.' named entity 'AXONAL DAMAGE' named entity 'MEDIATORS OF INFLAMMATION' named entity 'MAKE' named entity 'INFLAMMATION' named entity 'STUDIES' named entity 'FORMATION' named entity 'RESULTS' named entity 'VARIOUS' named entity 'IMMUNE CELL' named entity 'SCLEROSING' named entity 'IMMUNE ACTIVATION' named entity 'KEY' named entity 'CHEMOKINE RECEPTORS' named entity 'SIGNIFICANCE' named entity 'Multiple sclerosis' named entity 'inflammation' named entity 'cell migration' named entity 'repair' named entity 'damage' named entity 'subsequent' named entity 'chemokine' named entity 'multiple sclerosis' named entity 'multiple sclerosis' named entity 'inflammation' named entity 'treatment of multiple sclerosis' named entity 'inflammatory disease' named entity 'DCs'

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