About: Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques

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About: Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques
Creator	Munster, Vincent Falzarano, Darryl Feldmann, Heinz Feldmann, Friederike Scott, Dana Haddock, Elaine Prescott, Joseph Dittmer, Dirk Hardcastle, Kath De Wit, Emmie Chen, Alan Emanuel, Byron Hsu, Yu Jacobus Munster, Vincent Martina, Eusebio
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) has recently emerged in the Middle East. Since 2012, there have been approximately 2,100 confirmed cases, with a 35% case fatality rate. Disease severity has been linked to patient health status, as people with chronic diseases or an immunocompromised status fare worse, although the mechanisms of disease have yet to be elucidated. We used the rhesus macaque model of mild MERS to investigate whether the immune response plays a role in the pathogenicity in relation to MERS-CoV shedding. Immunosuppressed macaques were inoculated with MERS-CoV and sampled daily for 6 days to assess their immune statues and to measure viral shedding and replication. Immunosuppressed macaques supported significantly higher levels of MERS-CoV replication in respiratory tissues and shed more virus, and virus disseminated to tissues outside of the respiratory tract, whereas viral RNA was confined to respiratory tissues in non-immunosuppressed animals. Despite increased viral replication, pathology in the lungs was significantly lower in immunosuppressed animals. The observation that the virus was less pathogenic in these animals suggests that disease has an immunopathogenic component and shows that inflammatory responses elicited by the virus contribute to disease.
has issue date	2018-02-12(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.00205
bibo:pmid	29483914
has license	cc-by
sha1sum (hex)	87d23553b1e4abc9f23750121d6259b10da73387
schema:url	https://doi.org/10.3389/fimmu.2018.00205
resource representing a document's title	Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques
has PubMed Central identifier	PMC5816332
has PubMed identifier	29483914
schema:publication	Front Immunol
resource representing a document's body	covid:87d23553b1e4abc9f23750121d6259b10da73387#body_text
is schema:about of	named entity 'rhesus macaque' named entity 'virus' named entity 'health' named entity 'Despite' named entity 'mechanisms' named entity 'replication' named entity 'confirmed' named entity 'daily' named entity 'assess' named entity 'PATHOGENICITY' named entity 'RHESUS MACAQUES' named entity 'LOWER' named entity 'THESE' named entity 'SUPPORTED' named entity 'STATUS' named entity 'HAVE' named entity 'MACAQUES' named entity 'MODEL OF' named entity 'INCREASED' named entity 'PEOPLE' named entity 'TO MEASURE' named entity 'DISSEMINATED' named entity 'MIDDLE EAST' named entity 'ELICITED BY' named entity 'ASSESS' named entity 'LEVELS' named entity 'CHRONIC DISEASES' named entity 'USED' named entity 'PATHOLOGY' named entity 'MECHANISMS' named entity 'IMMUNOCOMPROMISED' named entity 'REPLICATION' named entity 'CASE FATALITY RATE' named entity 'RESPIRATORY' named entity 'INFLAMMATORY RESPONSES' named entity 'DAYS' named entity 'PLAYS' named entity 'DISEASE SEVERITY' named entity 'VIRAL REPLICATION' named entity 'VIRAL RNA' named entity 'APPROXIMATELY' named entity 'MERS' named entity 'THE LUNGS' named entity 'CONFIRMED' named entity 'TO INVESTIGATE' named entity 'PATIENT HEALTH STATUS' named entity 'ROLE' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'RESPIRATORY TRACT' named entity 'TISSUES' named entity 'RECENTLY' named entity 'VIRAL SHEDDING' named entity 'VIRUS' named entity 'IMMUNE RESPONSE' named entity 'CONTRIBUTE ' named entity 'OUTSIDE' named entity 'NON-' named entity 'WORSE' named entity 'MERS-COV' named entity 'VIRAL SHEDDING' named entity 'MILD' named entity 'THEIR' named entity 'SAMPLED' named entity 'OBSERVATION' named entity 'RELATION' named entity 'IMMUNE' named entity 'IMMUNOCOMPROMISED'

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