About: TRAIL-based gene delivery and therapeutic strategies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TRAIL-based gene delivery and therapeutic strategies
Creator	Li, Jian Huang, Yong-Zhuo Wang, Hui-Yuan Zhong, Hui-Hai
Source	PMC
abstract	TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), also known as APO2L, belongs to the tumor necrosis factor family. By binding to the death receptor 4 (DR4) or DR5, TRAIL induces apoptosis of tumor cells without causing side toxicity in normal tissues. In recent years TRAIL-based therapy has attracted great attention for its promise of serving as a cancer drug candidate. However, the treatment efficacy of TRAIL protein was under expectation in the clinical trials because of the short half-life and the resistance of cancer cells. TRAIL gene transfection can produce a “bystander effect” of tumor cell killing and provide a potential solution to TRAIL-based cancer therapy. In this review we focus on TRAIL gene therapy and various design strategies of TRAIL DNA delivery including non-viral vectors and cell-based TRAIL therapy. In order to sensitize the tumor cells to TRAIL-induced apoptosis, combination therapy of TRAIL DNA with other drugs by the codelivery methods for yielding a synergistic antitumor efficacy is summarized. The opportunities and challenges of TRAIL-based gene delivery and therapy are discussed.
has issue date	2019-08-23(xsd:dateTime)
bibo:doi	10.1038/s41401-019-0287-8
bibo:pmid	31444476
has license	cc-by
sha1sum (hex)	876e3b3d4d06aacf2cfab1517ee653d15e2e9bc5
schema:url	https://doi.org/10.1038/s41401-019-0287-8
resource representing a document's title	TRAIL-based gene delivery and therapeutic strategies
has PubMed Central identifier	PMC6889127
has PubMed identifier	31444476
schema:publication	Acta Pharmacol Sin
resource representing a document's body	covid:876e3b3d4d06aacf2cfab1517ee653d15e2e9bc5#body_text
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