About: Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks

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About: Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks
Creator	Huang, Yhu-Chering Tsao, Kuo-Chien Chang, Kuang-Yi Gong, Yu-Nong Hsieh, Yu-Chia Huang, Ching-Tai
Source	Medline; PMC
abstract	A novel pandemic influenza A(H1N1)pdm09 virus emerged in 2009 globally, and it continues to circulate in humans. The National Influenza Surveillance Network in Taiwan identified five A(H1N1)pdm09-predominant seasons, representing the 2009/2010, 2010/2011, 2012/2013, 2013/2014, and 2015/2016 outbreaks from 2009 to 2016. Independently, a retrospective cohort study (which enrolled 639 infected patients during the five seasons) was conducted at Chang Gung Memorial Hospital to explore the risk factors associated with influenza A(H1N1)pdm09-related complications. A phylogenetic analysis of hemagglutinin (HA) sequences showed that the circulating A(H1N1)pdm09 virus belonged to clades 1, 2, and 8 in 2009/2010; clades 3, 4, 5, and 7 in 2010/2011; clades 7 and 6C in 2012/2013; clades 6B in 2013/2014; and 6B/6B.1/6B.2 in 2015/2016. Compared to individuals infected in non-6B/6B.1/6B.2 seasons (2009/2010, 2010/2011, and 2012/2013), those infected in 6B/6B.1/6B.2 seasons (2013/2014 and 2015/2016) were at higher risk for influenza-related complications (adjusted odds ratio [aOR]: 1.6, 95% confidence interval [CI]: 1.0–2.8), pneumonia (aOR: 1.78, 95% CI: 1.04–3.04), mechanical ventilation (aOR: 2.6, 95% CI: 1.2–5.6), and acute respiratory distress syndrome (aOR: 5.5, 95% CI: 1.9–15.9). For the increased severity of infection during the influenza A(H1N1)pdm09 clade 6B/6B.1/6B.2 seasons, aspects related to the antigenic change of A(H1N1)pdm09 virus, immune response of the host, and environmental factors required further investigation.
has issue date	2018-10-23(xsd:dateTime)
bibo:doi	10.1038/s41598-018-34077-4
bibo:pmid	30353096
has license	cc-by
sha1sum (hex)	86a11741a321a657e22fd7d94af6193d27cc6f5f
schema:url	https://doi.org/10.1038/s41598-018-34077-4
resource representing a document's title	Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks
has PubMed Central identifier	PMC6199313
has PubMed identifier	30353096
schema:publication	Sci Rep
resource representing a document's body	covid:86a11741a321a657e22fd7d94af6193d27cc6f5f#body_text
is schema:about of	named entity 'LABORATORY' named entity 'PREDOMINANT' named entity 'CONFIRMED' named entity 'ASSOCIATED WITH' named entity 'CIRCULATE' named entity 'IDENTIFIED' named entity 'CHANG GUNG MEMORIAL HOSPITAL' named entity '1.04' named entity 'NOVEL' named entity 'INVESTIGATION' named entity 'SEVERITY' named entity 'PANDEMIC' named entity '1.2' named entity 'RETROSPECTIVE COHORT STUDY' named entity '5.5' named entity 'OUTBREAKS' named entity 'INFLUENZA A' named entity 'CLADE' named entity 'VIRUS' named entity 'PNEUMONIA' named entity 'ODDS RATIO' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'HEMAGGLUTININ' named entity 'PATIENTS' named entity 'MECHANICAL VENTILATION' named entity 'HUMANS' named entity 'AT HIGHER RISK' named entity 'GLOBALLY' named entity 'CHANGE' named entity '1.6' named entity 'COMPLICATIONS' named entity 'REQUIRED' named entity 'CONFIDENCE INTERVAL' named entity 'INFLUENZA A' named entity 'IMMUNE RESPONSE' named entity '5.6' named entity 'INFLUENZA SURVEILLANCE' named entity 'SEQUENCES' named entity 'INFECTED' named entity 'NETWORK' named entity 'HOST' named entity 'ENROLLED' named entity '2.6' named entity 'RISK FACTORS' named entity 'RELATED' named entity 'ENVIRONMENTAL FACTORS' named entity 'INCREASED' named entity 'TAIWAN' named entity '2015' named entity 'INFECTION' named entity 'CLADE' named entity 'INFLUENZA' named entity 'NATIONAL' named entity '1.9' named entity 'SEASONS' named entity 'CLINICAL CHARACTERISTICS' named entity 'PATIENTS' named entity 'CIRCULATING' named entity 'PHYLOGENETIC ANALYSIS' covid:arg/86a11741a321a657e22fd7d94af6193d27cc6f5f named entity '1, 2' named entity 'virus' named entity 'H1N1' named entity 'higher risk' named entity 'confidence interval' named entity 'virus' named entity 'A(H1N1)pdm09' named entity 'phylogenetic analysis' named entity 'influenza' named entity 'Chang Gung Memorial Hospital' named entity 'Clinical characteristics' named entity 'clade' named entity 'virus' named entity 'H1N1' named entity 'underlying diseases' named entity 'vaccines'

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