About: Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins

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About: Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins
Creator	Madsen, Jens Skylaris, Chris-Kriton Watson, Alastair Clark, Howard Phipps, Maximillian Health, Child
Source	Medline; PMC
abstract	Innate recognition of viruses is an essential part of the immune response to viral pathogens. This is integral to the maintenance of healthy lungs, which are free from infection and efficient at gaseous exchange. An important component of innate immunity for identifying viruses is the family of C-type collagen-containing lectins, also known as collectins. These secreted, soluble proteins are pattern recognition receptors (PRRs) which recognise pathogen-associated molecular patterns (PAMPs), including viral glycoproteins. These innate immune proteins are composed of trimerized units which oligomerise into higher-order structures and facilitate the clearance of viral pathogens through multiple mechanisms. Similarly, many viral surface proteins form trimeric configurations, despite not showing primary protein sequence similarities across the virus classes and families to which they belong. In this review, we discuss the role of the lung collectins, i.e., surfactant proteins A and D (SP-A and SP-D) in viral recognition. We focus particularly on the structural similarity and complementarity of these trimeric collectins with the trimeric viral fusion proteins with which, we hypothesise, they have elegantly co-evolved. Recombinant versions of these innate immune proteins may have therapeutic potential in a range of infectious and inflammatory lung diseases including anti-viral therapeutics.
has issue date	2018-10-05(xsd:dateTime)
bibo:doi	10.1159/000492974
bibo:pmid	30293076
has license	cc-by
sha1sum (hex)	868b9ab09cae7afe1d1e2ad2f547adecd4d18ac6
schema:url	https://doi.org/10.1159/000492974
resource representing a document's title	Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins
has PubMed Central identifier	PMC6738215
has PubMed identifier	30293076
schema:publication	J Innate Immun
resource representing a document's body	covid:868b9ab09cae7afe1d1e2ad2f547adecd4d18ac6#body_text
is schema:about of	named entity 'PROTEINS' named entity 'proteins' named entity 'viral' named entity 'Defence' named entity 'proteins' named entity 'Structure' named entity 'Surfactant' named entity 'Journal' named entity 'IMMUNE' named entity 'FAMILIES' named entity 'EXCHANGE' named entity 'DISCUSS' named entity 'HAVE' named entity 'VIRAL' named entity 'MULTIPLE' named entity 'MAINTENANCE' named entity 'COMPONENT' named entity 'IMMUNE' named entity 'COLLAGEN' named entity 'IMPORTANT' named entity 'INNATE IMMUNITY' named entity 'IDENTIFYING' named entity 'LUNGS' named entity 'PROTEINS' named entity 'FOCUS' named entity 'THERAPEUTIC' named entity 'THERAPEUTICS' named entity 'VIRUS' named entity 'POTENTIAL' named entity 'FREE' named entity 'PROTEIN SEQUENCE' named entity 'CLEARANCE' named entity 'THESE' named entity 'PATHOGEN' named entity 'HIGHER' named entity 'VIRAL PATHOGENS' named entity 'SURFACTANT' named entity 'TYPE' named entity 'IMMUNE RESPONSE' named entity 'FAMILY' named entity 'AFFINITY' named entity 'FUSION' named entity 'SURFACTANT' named entity 'STRUCTURES' named entity 'RECOGNITION' named entity 'RESPONSE TO' named entity 'RECOMBINANT' named entity 'PATTERN RECOGNITION RECEPTORS' named entity 'COLLECTINS' named entity 'MECHANISMS' covid:arg/868b9ab09cae7afe1d1e2ad2f547adecd4d18ac6 named entity 'EVOLVED' named entity 'VIRAL FUSION PROTEINS' named entity 'CLASSES' named entity 'LOWER' named entity 'HEALTHY' named entity 'SP-D' named entity 'RANGE' named entity 'INNATE IMMUNITY' named entity 'STRUCTURE' named entity 'COLLECTINS' named entity 'VIRAL FUSION PROTEINS' named entity 'AIRWAYS' named entity 'KEYWORDS' named entity 'UPPER' named entity 'JOURNAL ' named entity 'COMPLEMENTARITY' named entity 'KNOWN' named entity 'VIRUSES' named entity 'EFFICIENT' named entity 'INFLAMMATORY' named entity 'MOLECULAR' named entity 'ACROSS' named entity 'LECTINS' named entity 'GLYCOPROTEINS' named entity 'PATTERNS'

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