About: Rhinovirus-Induced Oxidative Stress and Interleukin-8 Elaboration Involves p47-phox but Is Independent of Attachment to Intercellular Adhesion Molecule-1 and Viral Replication

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About: Rhinovirus-Induced Oxidative Stress and Interleukin-8 Elaboration Involves p47-phox but Is Independent of Attachment to Intercellular Adhesion Molecule-1 and Viral Replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rhinovirus-Induced Oxidative Stress and Interleukin-8 Elaboration Involves p47-phox but Is Independent of Attachment to Intercellular Adhesion Molecule-1 and Viral Replication
Creator	Turner, Ronald Biagioli, Matthew Kaul, Poonam Singh, Inderjit
Source	Medline; PMC
abstract	Virus-induced elaboration of proinflammatory cytokines is mediated by virus-induced oxidative stress. The purpose of these studies was to determine the source of the virus-induced oxidative stress. Inhibition of viral replication with antibody to intercellular adhesion molecule-1 had no effect on virus-induced oxidative stress or interleukin-8 (IL-8) response (597 ± 88 vs. 668 ± 78 pg/mL in control cells). Treatment of cells with diphenylene iodonium inhibited virus-induced oxidative stress and IL-8 elaboration, but allopurinol, ibuprofen, and rotenone had no effect. Studies in cell lines produced from a patient with gp91-phox deficiency revealed normal responses. In contrast, the oxidative response was decreased and the IL-8 concentration was 227 ± 36 pg/mL in cells from a patient with p47-phox deficiency, compared with 664 ± 48 pg/mL in control cells. These studies suggest that the stimulation of reactive oxygen species by viral challenge occurs at the cell surface even in the absence of viral replication and involves a flavoprotein that may act in concert with p47-phox.
has issue date	2000-06-01(xsd:dateTime)
bibo:doi	10.1086/315504
bibo:pmid	10837166
has license	no-cc
sha1sum (hex)	865402848ce381ad6e7c7cdaf859b94a421fd79d
schema:url	https://doi.org/10.1086/315504
resource representing a document's title	Rhinovirus-Induced Oxidative Stress and Interleukin-8 Elaboration Involves p47-phox but Is Independent of Attachment to Intercellular Adhesion Molecule-1 and Viral Replication
has PubMed Central identifier	PMC7109975
has PubMed identifier	10837166
schema:publication	J Infect Dis
resource representing a document's body	covid:865402848ce381ad6e7c7cdaf859b94a421fd79d#body_text
is schema:about of	named entity 'P47-PHOX' named entity 'BUT' named entity 'inhibited' named entity 'viral' named entity 'cells' named entity 'rotenone' named entity 'RHINOVIRUS' named entity 'INTERLEUKIN-8 ' named entity 'VIRUS' named entity 'DECREASED' named entity 'GP91-PHOX' named entity 'DEFICIENCY' named entity 'IODONIUM' named entity 'DIPHENYLENE' named entity 'SUGGEST' named entity 'CONCENTRATION' named entity 'THESE' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'SPECIES' named entity '80%' named entity 'CONCERT' named entity 'CELL SURFACE' named entity 'CONTRAST' named entity 'ACT' named entity 'ALLOPURINOL' named entity 'REACTIVE' named entity 'OXIDATIVE STRESS' named entity 'ANTIBODY' named entity 'REVEALED' named entity '597' named entity 'MEDIATED' named entity 'DETERMINE' named entity 'IL-8' named entity 'INTERCELLULAR ADHESION MOLECULE-1' named entity 'INTERLEUKIN-8 ' covid:arg/865402848ce381ad6e7c7cdaf859b94a421fd79d named entity 'ELABORATION' named entity 'CHALLENGE' named entity 'P47-PHOX' named entity 'INHIBITION OF VIRAL REPLICATION' named entity 'NO EFFECT' named entity 'ABSENCE OF' named entity 'INDUCED' named entity 'VIRAL REPLICATION' named entity 'PATIENT' named entity 'SOURCE' named entity 'TREATMENT' named entity 'INHIBITED' named entity 'ATTACHMENT' named entity 'VIRAL REPLICATION' named entity 'INDUCED' named entity 'OXIDATIVE STRESS' named entity 'BUT' named entity 'INTERCELLULAR ADHESION MOLECULE-1' named entity 'ELABORATION' named entity 'OXYGEN' named entity 'CONTROL' named entity 'FLAVOPROTEIN' named entity 'PURPOSE' named entity 'IBUPROFEN' named entity 'INDEPENDENT OF' named entity 'STIMULATION' named entity 'ROTENONE' named entity 'OXIDATIVE' named entity 'COMPARED' named entity 'VIRAL' named entity 'NORMAL' named entity 'STUDIES' named entity 'CELLS' named entity 'RESPONSES' named entity 'RESPONSE' named entity 'CELL LINES' named entity 'oxidative stress' named entity 'cell lines' named entity 'revealed' named entity 'IL-8' named entity 'determine' named entity 'response'

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