About: Cyclophilins as Modulators of Viral Replication

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cyclophilins as Modulators of Viral Replication
Creator	Lee, Emily Tang, Hengli Frausto, Stephen
Source	Medline; PMC
abstract	Cyclophilins are peptidyl‐prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for cyclophilins to serve as a drug target for antiviral therapy is evidenced by the success of non-immunosuppressive cyclophilin inhibitors (CPIs), including Alisporivir, in clinical trials targeting hepatitis C virus infection. In addition, as cyclophilins are implicated in the predisposition to, or severity of, various diseases, the ability to specifically and effectively modulate their function will prove increasingly useful for disease intervention. In this review, we will summarize the evidence of cyclophilins as key mediators of viral infection and prospective drug targets.
has issue date	2013-07-11(xsd:dateTime)
bibo:doi	10.3390/v5071684
bibo:pmid	23852270
has license	cc-by
sha1sum (hex)	860ddc48c73d4757ceb161a9b43e73138b6b94a4
schema:url	https://doi.org/10.3390/v5071684
resource representing a document's title	Cyclophilins as Modulators of Viral Replication
has PubMed Central identifier	PMC3738956
has PubMed identifier	23852270
schema:publication	Viruses
resource representing a document's body	covid:860ddc48c73d4757ceb161a9b43e73138b6b94a4#body_text
is schema:about of	named entity 'life cycles' named entity 'cyclophilins' named entity 'mechanisms' named entity 'effectively' named entity 'TO SERVE AS' named entity 'DRUG TARGETS' named entity 'DIVERSE' named entity 'USEFUL' named entity 'POTENTIAL' named entity 'VIRUSES' named entity 'ALISPORIVIR' named entity 'CLINICAL TRIALS' named entity 'EITHER' named entity 'FOLDING' named entity 'MEDIATORS' named entity 'INTERVENTION' named entity 'THESE' named entity 'PREDISPOSITION' named entity 'CYCLOPHILINS' named entity 'DISEASE' named entity 'TARGETING' named entity 'DISEASES' named entity 'BUT' named entity 'PROSPECTIVE' named entity 'LIFE CYCLES' named entity 'NATURE' named entity 'ROLES' named entity 'MOUNTING' named entity 'IMPORTANT' named entity 'MODULATE' named entity 'DRUG TARGET' named entity 'THEIR' named entity 'ANTIVIRAL THERAPY' named entity 'MECHANISMS' named entity 'CYCLOPHILIN' named entity 'PROLYL' named entity 'MODULATORS' named entity 'HEPATITIS C VIRUS INFECTION' named entity 'CYCLOPHILINS' named entity 'VIRAL REPLICATION' named entity 'ADDITION' named entity 'SUCCESS' named entity 'FUNCTION' named entity 'SEVERITY' named entity 'PROPER' named entity 'EVIDENCE OF' named entity 'EVIDENCE' named entity 'VIRAL INFECTION' named entity 'ISOMERASES' named entity 'DEFINED' named entity 'IMMUNOSUPPRESSIVE' named entity 'INCLUDING' named entity 'INHIBITORS' named entity 'PROTEINS' named entity 'REVIEW' named entity 'CIS' named entity 'NEGATIVE' named entity 'PEPTIDYL' named entity 'KEY' named entity 'VARIOUS' named entity 'POSITIVE' named entity 'NON-' named entity 'CERTAIN' named entity 'drug targets' named entity 'hepatitis C virus' named entity 'viruses' named entity 'disease' named entity 'nature' named entity 'folding' named entity 'cyclophilins' named entity 'cyclophilins' named entity 'positive or negative' named entity 'antiviral therapy' named entity 'cis' named entity 'cyclophilins' named entity 'drug targets' named entity 'trans' named entity 'immunosuppressive' named entity 'conserved regions'

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