About: The Screening Research of NF-κB Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS

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About: The Screening Research of NF-κB Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Screening Research of NF-κB Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS
Creator	Bai, Gang Deng, Yanfang Jiang, Min Liu, Wenjuan Lu, Yujie Zhang, Man
Source	PMC
abstract	Inflammation is a common and important pathological process, and nuclear factor-κB (NF-κB) is a key mediator of it. Moutan Cortex (MC), the dried root cortex of Paeonia suffruticosa Andr., is widely used as a remedy for the treatment of inflammatory diseases in Asian region. However, there are few studies on the systematic identification of NF-κB inhibitors of MC. In this study, the effect of inhibiting NF-κB activation of MC was assessed at the cellular level using a tumor necrosis factor-α (TNF-α) induced inflammatory model. Subsequently, ultra-performance liquid chromatography-quadrupole/time of flight-mass spectrometry (UPLC-Q/TOF-MS) combined with biological activity assay was established to screen and identify potential anti-inflammatory ingredients in MC. The results revealed that MC significantly inhibited the activation of NF-κB. Seven potential NF-κB inhibitors were screened from MC, including oxypaeoniflorin, paeoniflorin, galloylpaeoniflorin, benzoyloxypaeoniflorin, mudanpioside C, gallic acid, and paeonol. Among them, the NF-κB inhibitor activity of galloylpaeoniflorin, benzoyloxypaeoniflorin, and mudanpioside C is first reported here. In conclusion, the anti-inflammatory activity of MC was associated with the seven components mentioned above. And the bioactivity-integrated UPLC-Q/TOF which contains both chemical and bioactive details is suitable for screening active ingredients from natural medicines.
has issue date	2019-03-03(xsd:dateTime)
bibo:doi	10.1155/2019/6150357
bibo:pmid	30941197
has license	cc-by
sha1sum (hex)	85c6f63e581817cce1d68e6a5bb856fdbe390d17
schema:url	https://doi.org/10.1155/2019/6150357
resource representing a document's title	The Screening Research of NF-κB Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS
has PubMed Central identifier	PMC6420966
has PubMed identifier	30941197
schema:publication	Evid Based Complement Alternat Med
resource representing a document's body	covid:85c6f63e581817cce1d68e6a5bb856fdbe390d17#body_text
is schema:about of	named entity 'MOUTAN CORTEX' named entity 'UPLC' named entity 'BASED' named entity 'INHIBITORS' named entity 'INTEGRATED' named entity 'SCREENING' named entity 'BIOACTIVITY' named entity 'RESEARCH' named entity 'UPLC' named entity 'NF-B' named entity 'apoptosis' named entity 'synthetic drugs' named entity 'supernatants' named entity 'LEA' named entity 'IL-6' named entity 'amide' named entity 'Bio-Rad' named entity 'MS/MS' named entity 'structural analysis' named entity 'cytotoxicity' named entity 'cytokines' named entity 'ultraviolet irradiation' named entity 'inhibitory activity' named entity 'methanol' named entity 'paeoniflorin' named entity 'DMEM' named entity 'paeoniflorin' named entity 'bladder cancer' named entity 'NF-B' named entity 'Complementary and Alternative Medicine' named entity 'expression levels' named entity 'HEK 293' named entity 'infection' named entity 'pus' named entity 'MS/MS' named entity 'organism' named entity 'gallic acid' named entity 'NF-B' named entity 'animal experiments' named entity 'Complementary and Alternative Medicine' named entity 'paeonol' named entity 'NF-B' named entity 'paeoniflorin' named entity 'osteoporosis' named entity 'high glucose' named entity 'lipopolysaccharide' named entity 'paeoniflorin' named entity 'paeonol' named entity 'signaling pathway' named entity 'luciferase' named entity 'UPLC' named entity 'bronchial epithelial cells' named entity 'luciferase' named entity 'positive control' named entity 'inflammatory cytokines' named entity 'molecular weight' named entity 'NF-B' named entity 'freeze-dried' named entity 'acute lung injury' named entity 'NF-B' named entity 'anti-inflammatory' named entity 'paeonol' named entity 'anti-inflammatory effect' named entity 'Leucine enkephalin' named entity 'atherosclerosis' named entity 'UPLC' named entity 'NF-B' named entity '21%' named entity 'signaling pathway' named entity 'supernatant' named entity 'NF-B' named entity 'Rockville, MD' named entity 'NSAID' named entity 'Paeonia suffruticosa' named entity 'recombinant' named entity 'pharmacological'

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