About: Viral Control of Mitochondrial Apoptosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral Control of Mitochondrial Apoptosis
Creator	Galluzzi, Lorenzo Kroemer, Guido Morselli, Eugenia Brenner, Catherine Touat, Zahia
Source	Medline; PMC
abstract	Throughout the process of pathogen–host co-evolution, viruses have developed a battery of distinct strategies to overcome biochemical and immunological defenses of the host. Thus, viruses have acquired the capacity to subvert host cell apoptosis, control inflammatory responses, and evade immune reactions. Since the elimination of infected cells via programmed cell death is one of the most ancestral defense mechanisms against infection, disabling host cell apoptosis might represent an almost obligate step in the viral life cycle. Conversely, viruses may take advantage of stimulating apoptosis, either to kill uninfected cells from the immune system, or to induce the breakdown of infected cells, thereby favoring viral dissemination. Several viral polypeptides are homologs of host-derived apoptosis-regulatory proteins, such as members of the Bcl-2 family. Moreover, viral factors with no homology to host proteins specifically target key components of the apoptotic machinery. Here, we summarize the current knowledge on the viral modulation of mitochondrial apoptosis, by focusing in particular on the mechanisms by which viral proteins control the host cell death apparatus.
has issue date	2008-05-30(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1000018
bibo:pmid	18516228
has license	cc-by
sha1sum (hex)	857137889eef45edb1a66c1950f0e0ca27ad63a4
schema:url	https://doi.org/10.1371/journal.ppat.1000018
resource representing a document's title	Viral Control of Mitochondrial Apoptosis
has PubMed Central identifier	PMC2376094
has PubMed identifier	18516228
schema:publication	PLoS Pathog
resource representing a document's body	covid:857137889eef45edb1a66c1950f0e0ca27ad63a4#body_text
is schema:about of	named entity 'Apoptosis' named entity 'HOST' named entity 'PATHOGEN' named entity 'PROCESS' named entity 'CONTROL' named entity 'MITOCHONDRIAL' named entity 'VIRAL' named entity 'APOPTOSIS' named entity 'Apoptosis' named entity 'proteomics' named entity 'VDAC' named entity 'mitochondria' named entity 'VP3' named entity 'proapoptotic' named entity 'murine' named entity 'effector' named entity 'NS3' named entity 'sheeppox' named entity 'extracellular domain' named entity 'adenine' named entity 'caspase cascade' named entity 'etiological' named entity 'gene expression' named entity 'virus' named entity 'apoptosis' named entity 'Bcl-2' named entity 'MMP' named entity 'MMP' named entity 'mitochondrial' named entity 'host cell' named entity 'caspase activation' named entity 'Bcl-2' named entity 'Homologs' named entity 'hydrophobic' named entity 'plasma membrane' named entity 'host cells' named entity 'intracellular' named entity 'protein' named entity 'C-terminus' named entity 'VSV' named entity 'recombinant' named entity 'viral cycle' named entity 'cell shrinkage' named entity 'Fas' named entity 'hexokinase' named entity 'sarco' named entity 'apoptosis' named entity 'Apoptosis' named entity 'Bak' named entity 'pyknosis' named entity 'Vpr' named entity 'endonuclease' named entity 'mitochondria' named entity 'viruses' named entity 'flaccid paralysis' named entity 'fragmentation' named entity 'proteolytically processed' named entity 'mitochondrial fission' named entity 'Bax' named entity 'glycoprotein' named entity 'endocytic pathway' named entity 'Bcl-2' named entity 'crosstalk' named entity 'DNA fragmentation' named entity 'vpr' named entity 'cytosol' named entity 'apoptosis' named entity 'mitochondrial respiratory chain' named entity 'orthologs' named entity 'leporipoxvirus' named entity 'protein' named entity 'peripheral blood mononuclear cells' named entity 'tertiary structure' named entity 'EGFR' named entity 'Tat' named entity 'folded protein' named entity 'BH3'

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