About: Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection

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About: Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection
Creator	Qin, Chuan Zhang, Lianfeng Suzuki, Yasuhiro Jiang, Hong Hattori, Toshio Sugamura, Kazuo Zhuang, Min Li, Xiaoguang Ling, Hong Saitoh, Hiroki Tanaka, Takashi Xiao, Peng Yang, Baofeng
Source	Elsevier; Medline; PMC
abstract	Abstract We found that the butanol fraction of Cinnamomi Cortex (CC/Fr.2) showed moderate inhibitory activity in wild-type severe acute respiratory syndrome coronavirus (wtSARS-CoV) and HIV/SARS-CoV S pseudovirus infections. The inhibition on pseudovirus was also seen in cells pretreated with the CC and CC/Fr.2 (IC50S, 283.4±16.3 and 149.5±13.5μg/ml, respectively), however the highest activities on wtSARS-CoV were observed when the viruses were treated by the extracts before challenging (IC50S, 43.1±2.8 and 7.8±0.3μg/ml; SIs, 8.4 and 23.1, respectively). Among the compounds fractionated from CC, procyanidin A2 and procyanidin B1 showed moderate anti-wtSARS-CoV activity (IC50S, 29.9±3.3 and 41.3±3.4μM; SIs, 37.35 and 15.69, respectively). We also sought to determine whether they could interfere with the clathrin-dependent endocytosis pathway using transferrin receptor (TfR) as an indicator. CC/Fr.2 inhibited the internalization of TfR but the procyanidins did not. Taken together, CC/Fr.2 contains unknown substances, that could inhibit the infection, probably by interfering with endocytosis, and it also contains procyanidins that did not inhibit the internalization but inhibited the infection. Therefore, CC extracts contain anti-virus activities that act through distinct mechanisms according to differences in the compounds or mixtures.
has issue date	2009-04-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2009.02.001
bibo:pmid	19428598
has license	els-covid
sha1sum (hex)	85014021fd768128ce2b9146a156190ccdad429e
schema:url	https://doi.org/10.1016/j.antiviral.2009.02.001
resource representing a document's title	Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection
has PubMed Central identifier	PMC7114128
has PubMed identifier	19428598
schema:publication	Antiviral Research
resource representing a document's body	covid:85014021fd768128ce2b9146a156190ccdad429e#body_text
is schema:about of	named entity 'EXTRACT' named entity 'PROCYANIDINS' named entity 'infections' named entity 'anti-virus' named entity 'HIGHEST' named entity 'PROCYANIDINS' named entity 'CINNAMOMI CORTEX' named entity 'CONTAINS' named entity 'VIRUSES' named entity 'TRANSFERRIN RECEPTOR' named entity 'TAKEN' named entity 'BUT' named entity '149' named entity 'BUTANOL' named entity 'DETERMINE' named entity 'FRACTIONATED' named entity 'INHIBITED' named entity '50S' named entity '3.3' named entity '3.4' named entity '8.4' named entity 'INFECTION' named entity 'MODERATE' named entity 'SEEN' named entity 'ACTIVITIES' named entity 'ACTIVITY' named entity 'EXTRACTS' named entity 'ACT' named entity 'SUBSTANCES' named entity 'OBSERVED' named entity 'INHIBITION' named entity 'INHIBITORY ACTIVITY' named entity 'SIS' named entity 'SARS-COV INFECTION' named entity 'CELLS' named entity 'UNKNOWN' named entity 'INTERFERING' named entity 'ACCORDING' named entity 'PROBABLY' named entity 'INTERNALIZATION' named entity 'USING' named entity 'FRACTION OF' named entity 'CONTAIN' named entity 'VIRUS' named entity 'WILD-TYPE' named entity 'PROCYANIDIN A2' named entity 'ENDOCYTOSIS PATHWAY' named entity '0.3' named entity 'INFECTIONS' named entity 'INTERFERE' named entity 'DISTINCT' named entity 'MIXTURES' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'ENDOCYTOSIS' named entity 'BUTANOL' named entity 'CINNAMOMI CORTEX' named entity 'CLATHRIN-DEPENDENT ENDOCYTOSIS' named entity 'HIV' named entity '41.3' named entity 'TREATED' named entity 'DID' named entity 'PSEUDOVIRUS' named entity '283' named entity '13.5' named entity 'FOUND' named entity 'INDICATOR' named entity 'MECHANISMS' named entity 'PROCYANIDIN B1' named entity 'TFR'

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