About: Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence

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About: Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence
Creator	Herrler, Georg Yin, Xiangping Tong, Jie Meng, Fandan Wu, Nai-Huei Haas, Ludwig Krumbholz, Andi Zell, Roland Dürrwald, Ralf Fu, Yuguang Schmidtke, Michaela Su, Ang
topic	covid:84f28658054d29836738175ebaece51c439f4943#this
source	PMC
abstract	We analyzed the virulence of pandemic H1N1 2009 influenza A viruses in vivo and in vitro. Selected viruses isolated in 2009, 2010, 2014, and 2015 were assessed using an aerosol-mediated high-dose infection model for pigs as well as air-liquid interface cultures of differentiated airway epithelial cells. Using a dyspnea score, rectal temperature, lung lesions, and viral load in the lung as parameters, the strains from 2014–2015 were significantly less virulent than the strains isolated in 2009–2010. In vitro, the viruses from 2009–2010 also differed from the 2014–2015 viruses by increased release of infectious virus, a more pronounced loss of ciliated cells, and a reduced thickness of the epithelial cell layer. Our in vivo and in vitro results reveal an evolution of A(H1N1)pdm09 viruses toward lower virulence. Our in vitro culture system can be used to predict the virulence of influenza viruses.
has issue date	2019-05-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jiy719
bibo:pmid	30776304
has license	no-cc
sha1sum (hex)	84f28658054d29836738175ebaece51c439f4943
schema:url	https://doi.org/10.1093/infdis/jiy719
resource representing a document's title	Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence
has PubMed Central identifier	PMC7107423
has PubMed identifier	30776304
schema:publication	J Infect Dis
resource representing a document's body	covid:84f28658054d29836738175ebaece51c439f4943#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/84f28658054d29836738175ebaece51c439f4943
is schema:about of	named entity 'culture system' named entity 'virulence' named entity 'pigs' named entity 'evolution' named entity '2015' named entity 'dyspnea' named entity 'Airway' named entity 'Evolution' named entity 'JOURNAL ' named entity 'STUDIES' named entity 'EPITHELIAL CELLS' named entity 'LUNG' named entity 'ANALYZED' named entity 'OUR' named entity 'EPITHELIAL CELL' named entity 'INFLUENZA A' named entity 'RECTAL TEMPERATURE' named entity 'REVEAL' named entity 'USED' named entity 'AIR-LIQUID' named entity 'DIFFERENTIATED' named entity 'ASSESSED' named entity 'PARAMETERS' named entity 'CULTURES' named entity 'VIRULENCE' named entity 'CILIATED CELLS' named entity 'THICKNESS' named entity 'INFLUENZA A' named entity 'INFECTIOUS DISEASES' named entity 'SCORE' named entity 'INFECTION' named entity 'AIRWAY' named entity 'MEDIATED' named entity 'INTERFACE' named entity 'INFECTION MODEL' named entity 'IN VITRO CULTURE' named entity 'AIRWAY' named entity 'CELL LAYER' named entity 'INFLUENZA VIRUSES' named entity 'PORCINE' named entity 'PIGS' named entity 'HIGH-DOSE' named entity 'H1N1' named entity 'LESIONS' named entity 'VIRUS' named entity 'LESS VIRULENT' named entity 'BY INCREASED' named entity 'LOWER' named entity '2015' named entity 'REVEAL' named entity 'SYSTEM' named entity 'EPITHELIAL CELLS' named entity 'REDUCED' named entity 'USING' named entity 'VIRAL LOAD' named entity 'STRAINS' named entity 'PANDEMIC' named entity 'PIGS' named entity 'VIRUSES' named entity 'EVOLUTION' named entity 'LOWER' named entity 'IN VIVO' named entity 'IN VITRO' named entity 'RESULTS' named entity 'SELECTED' named entity 'PREDICT' named entity 'AEROSOL' named entity 'DYSPNEA'

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