About: Risk factors for death from canine parvoviral-related disease in Australia

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk factors for death from canine parvoviral-related disease in Australia
Creator	Kelman, Mark Ward, Michael Ling, Monika Norris, Jacqueline
Source	Elsevier; Medline; PMC
abstract	Canine parvovirus (CPV) is a highly contagious cause of serious and often fatal disease in dogs worldwide despite the availability of safe and efficacious vaccines. Although a number of studies have focussed on identifying risk factors in disease development, risk factors associated with death from CPV are largely unknown. In this study we analysed a total of 1451 CPV cases reported from an Australian surveillance system – using univariate and multivariate techniques – to determine significant risk factors associated with death and euthanasia. A crude case fatality rate of 42.3% was estimated – higher than has been reported previously. We found that 3.3% of CPV cases had a history of vaccination in the previous 12 months, despite having completed the primary puppy vaccination course. The majority (89.5%) of these cases occurred in dogs <12 months of age, indicating failure of the primary vaccination course to provide protective immunity (most likely due to interference of the vaccine antigen with maternal antibodies but other reasons are discussed). Extending the age at which the final puppy vaccination is administered might be one of several strategies to consider. The final multivariate model showed that in non-litter CPV cases, risk of death was significantly associated with season of diagnosis (summer) and pedigree type (hounds and non-sporting dogs). Euthanasia in non-litter CPV cases was significantly associated with season of diagnosis (summer), state of residence (Northern Territory/South Australia/Tasmania combined), age (<six months) and vaccination status (unvaccinated and unknown). No significant risk factors associated with death were identified in cases in which there was more than one puppy in a litter infected. The risk factors identified in this study can be used as prognostic indicators for veterinarians faced with CPV cases. The possible explanations for the associations identified and their clinical relevance to CPV case outcome are discussed
has issue date	2012-08-17(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2012.02.034
bibo:pmid	22424864
has license	no-cc
sha1sum (hex)	84c7307105200078cf563dfd2a014bd1c5ad80b5
schema:url	https://doi.org/10.1016/j.vetmic.2012.02.034
resource representing a document's title	Risk factors for death from canine parvoviral-related disease in Australia
has PubMed Central identifier	PMC7133604
has PubMed identifier	22424864
schema:publication	Vet Microbiol
resource representing a document's body	covid:84c7307105200078cf563dfd2a014bd1c5ad80b5#body_text
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