About: CEACAM1 in Liver Injury, Metabolic and Immune Regulation

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About: CEACAM1 in Liver Injury, Metabolic and Immune Regulation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CEACAM1 in Liver Injury, Metabolic and Immune Regulation
Creator	Tiegs, Gisa Wagener, Christoph Najjar, Sonia Horst, Andrea
Source	PMC
abstract	Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells. CEACAM1 is a differentiation antigen involved in the maintenance of epithelial polarity that is induced during hepatocyte differentiation and liver regeneration. CEACAM1 regulates insulin sensitivity by promoting hepatic insulin clearance, and controls liver tolerance and mucosal immunity. Obese insulin-resistant humans with non-alcoholic fatty liver disease manifest loss of hepatic CEACAM1. In mice, deletion or functional inactivation of CEACAM1 impairs insulin clearance and compromises metabolic homeostasis which initiates the development of obesity and hepatic steatosis and fibrosis with other features of non-alcoholic steatohepatitis, and adipogenesis in white adipose depot. This is followed by inflammation and endothelial and cardiovascular dysfunctions. In obstructive and inflammatory liver diseases, soluble CEACAM1 is shed into human bile where it can serve as an indicator of liver disease. On immune cells, CEACAM1 acts as an immune checkpoint regulator, and deletion of Ceacam1 gene in mice causes exacerbation of inflammation and hyperactivation of myeloid cells and lymphocytes. Hence, hepatic CEACAM1 resides at the central hub of immune and metabolic homeostasis in both humans and mice. This review focuses on the regulatory role of CEACAM1 in liver and biliary tract architecture in health and disease, and on its metabolic role and function as an immune checkpoint regulator of hepatic inflammation.
has issue date	2018-10-11(xsd:dateTime)
bibo:doi	10.3390/ijms19103110
bibo:pmid	30314283
has license	cc-by
sha1sum (hex)	84bafc34e5e1118ed2da16a02c87e472e0dd0d4c
schema:url	https://doi.org/10.3390/ijms19103110
resource representing a document's title	CEACAM1 in Liver Injury, Metabolic and Immune Regulation
has PubMed Central identifier	PMC6213298
has PubMed identifier	30314283
schema:publication	Int J Mol Sci
resource representing a document's body	covid:84bafc34e5e1118ed2da16a02c87e472e0dd0d4c#body_text
is schema:about of	named entity 'lymphocytes' named entity 'adipogenesis' named entity 'liver' named entity 'focuses' named entity 'immune cells' named entity 'mice' named entity 'immunity' named entity 'induced' named entity 'differentiation' named entity 'diseases' named entity 'endothelial' named entity 'function' named entity 'hyperactivation' named entity 'humans' named entity 'metabolic' named entity 'myeloid' named entity 'endothelial' named entity 'inflammation' named entity 'acts' named entity 'hub' named entity 'non-alcoholic fatty liver disease' named entity 'CEACAM1' named entity 'hepatic' named entity 'liver diseases' named entity 'endothelial' named entity 'CEACAM1' named entity 'CEACAM1' named entity 'homeostasis' named entity 'cardiovascular' named entity 'Carcinoembryonic antigen' named entity 'insulin' named entity 'immune checkpoint' named entity 'immune cells' named entity 'liver' named entity 'Immune Regulation' named entity 'granzyme' named entity 'liver transplantation' named entity 'Ceacam1' named entity 'visceral adiposity' named entity 'transgenic' named entity 'endothelia' named entity 'gene' named entity 'CEACAM1' named entity 'insulin' named entity 'hyperphosphorylation' named entity 'leukocytes' named entity 'CEACAM1' named entity 'insulin' named entity 'Treg' named entity 'rheumatoid arthritis' named entity 'type 1 diabetes' named entity 'insulin resistance' named entity 'hepatitis' named entity 'homophilic' named entity 'vesicles' named entity 'isoform' named entity 'infection' named entity 'ConA' named entity 'NASH' named entity 'upregulation' named entity 'adipose tissue' named entity 'CEACAM1' named entity 'NASH' named entity 'HNF4α' named entity 'recombinant' named entity 'CEACAM1' named entity 'isoform' named entity 'myeloid' named entity 'TIM-3' named entity 'HCCs' named entity 'CD4' named entity 'T cell' named entity 'insulin' named entity 'CEACAM1' named entity 'mice' named entity 'CEACAM1' named entity 'insulin' named entity 'protein'

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