About: Difficulties in demonstrating long term immunity in FeLV vaccinated cats due to increasing age-related resistance to infection

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About: Difficulties in demonstrating long term immunity in FeLV vaccinated cats due to increasing age-related resistance to infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Difficulties in demonstrating long term immunity in FeLV vaccinated cats due to increasing age-related resistance to infection
Creator	Bruce, Lynn Childers, Tedd Greenslade, Juliet Holcroft, Catherine Saunders, Gillian Scobey, Andy Sture, Gordon Thompson, James Wilson, Stephen
Source	Medline; PMC
abstract	BACKGROUND: Feline leukaemia virus (FeLV) is a pathogen causing fatal illness in cats worldwide, and as such there is a high demand for products to protect against disease. The duration of immunity provided by an inactivated FeLV vaccine, Versifel FeLV, when administered to cats of the target age was determined. Kittens received two vaccinations when aged 7 to 9 weeks old, and were subsequently challenged up to 36 months later with the FeLV-A Glasgow isolate. RESULTS: In all studies, all of the younger aged control kittens showed persistent FeLV p27 antigenaemia confirming that the challenge virus was severe and efficacious. In contrast, the control cats did not show the required level of persistent antigenaemia, with a maximum of 45% cats affected in the middle duration study and only 10% in the longer study. However, apart from one animal in the short duration study, all of the cats vaccinated with Versifel FeLV were negative for persistent antigenaemia and can be considered treatment successes. CONCLUSION: In conclusion, we have shown that although age-related resistance to infection with a virulent FeLV challenge is evident from as early as 10 months of age, vaccination with Versifel FeLV may aid in the protection of cats from FeLV related disease up to three years after primary vaccination as kittens.
has issue date	2012-07-28(xsd:dateTime)
bibo:doi	10.1186/1746-6148-8-125
bibo:pmid	22839692
has license	cc-by
sha1sum (hex)	849541788c0fe480a2fb9e13b20f3937e759b249
schema:url	https://doi.org/10.1186/1746-6148-8-125
resource representing a document's title	Difficulties in demonstrating long term immunity in FeLV vaccinated cats due to increasing age-related resistance to infection
has PubMed Central identifier	PMC3433334
has PubMed identifier	22839692
schema:publication	BMC Vet Res
resource representing a document's body	covid:849541788c0fe480a2fb9e13b20f3937e759b249#body_text
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