About: MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

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About: MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells
Creator	Feng, Qian Zoll, Jan Hur, Sun Langereis, Martijn Peisley, Alys Virgen-Slane, Richard Semler, Bert Van Kuppeveld, Frank Van Rij, Ronald Hato, Stanleyson
Source	Elsevier; Medline; PMC
abstract	RIG-I and MDA5 are cytosolic RNA sensors that play a critical role in innate antiviral responses. Major advances have been made in identifying RIG-I ligands, but our knowledge of the ligands for MDA5 remains restricted to data from transfection experiments mostly using poly(I:C), a synthetic dsRNA mimic. Here, we dissected the IFN-α/β-stimulatory activity of different viral RNA species produced during picornavirus infection, both by RNA transfection and in infected cells in which specific steps of viral RNA replication were inhibited. Our results show that the incoming genomic plus-strand RNA does not activate MDA5, but minus-strand RNA synthesis and production of the 7.5 kbp replicative form trigger a strong IFN-α/β response. IFN-α/β production does not rely on plus-strand RNA synthesis and thus generation of the partially double-stranded replicative intermediate. This study reports MDA5 activation by a natural RNA ligand under physiological conditions.
has issue date	2012-11-29(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2012.10.005
bibo:pmid	23142662
has license	no-cc
sha1sum (hex)	845989d9e63ab61e5f9f5cf4292ea1001427a948
schema:url	https://doi.org/10.1016/j.celrep.2012.10.005
resource representing a document's title	MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells
has PubMed Central identifier	PMC7103987
has PubMed identifier	23142662
schema:publication	Cell Rep
resource representing a document's body	covid:845989d9e63ab61e5f9f5cf4292ea1001427a948#body_text
is schema:about of	named entity 'FORM' named entity 'identifying' named entity 'IFN-a' named entity 'RNA' named entity 'antiviral' named entity 'species' named entity 'OUR' named entity 'PHYSIOLOGICAL' named entity 'PARTIALLY' named entity 'LIGAND' named entity 'EXPERIMENTS' named entity 'CELLS' named entity 'RNA SYNTHESIS' named entity 'NATURAL' named entity 'CONDITIONS' named entity 'REPORTS' named entity 'SPECIES' named entity 'DISSECTED' named entity 'FORM' named entity 'STRONG' named entity 'PICORNAVIRUS INFECTION' named entity 'DATA' named entity 'DOES NOT' named entity 'RESPONSE' named entity 'RIG-I' named entity 'STEPS' named entity 'CYTOSOLIC' named entity 'TRIGGER' named entity 'VIRAL RNA' named entity 'KBP' named entity 'RESULTS' named entity 'MIMIC' named entity 'CELLS' named entity 'DIFFERENT' named entity 'MDA5' named entity 'PICORNAVIRUS' named entity 'ACTIVATION' named entity 'PLAY' named entity 'ANTIVIRAL' named entity 'DSRNA' named entity 'ROLE' named entity 'USING' named entity 'ACTIVATE' named entity 'POLY' named entity 'STRAND' named entity 'HERE' named entity 'RESTRICTED' named entity 'MAJOR' named entity 'PRODUCTION' named entity '2FB' named entity 'INCOMING' named entity '7.5' named entity 'IFN-A' named entity 'SPECIFIC' named entity 'RESPONSES' named entity 'SYNTHETIC' named entity 'BUT' named entity 'SENSORS' named entity '28I' named entity 'GENOMIC' named entity 'MINUS' named entity 'INTERMEDIATE' named entity 'RNA REPLICATION' named entity 'TRANSFECTION' named entity 'KNOWLEDGE' named entity 'INFECTED' named entity 'LIGANDS' named entity 'STUDY' named entity 'MDA5' named entity 'RNA' named entity 'HAVE' named entity 'INFECTED'

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