About: Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead
Creator	Li, Jian Chan, Hak-Kim Velkov, Tony Rahim, Nusaibah Zhou, Tony
Source	Elsevier; Medline; PMC
abstract	One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it affords delivery of sufficient therapeutic dosages directly to the primary site of infection, while minimizing the risks of systemic toxicity or avoiding potential suboptimal pharmacokinetics/pharmacodynamics associated with systemic drug exposure. This review provides an up-to-date treatise of approved and novel developmental inhaled anti-infective agents, with particular attention to effective strategies for their use, pulmonary pharmacokinetic properties and safety.
has issue date	2015-05-01(xsd:dateTime)
bibo:doi	10.1016/j.addr.2014.11.004
bibo:pmid	25446140
has license	green-oa
sha1sum (hex)	844be100b06408734894f48a4db56a05ba260621
schema:url	https://doi.org/10.1016/j.addr.2014.11.004
resource representing a document's title	Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead
has PubMed Central identifier	PMC4429008
has PubMed identifier	25446140
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:844be100b06408734894f48a4db56a05ba260621#body_text
is schema:about of	named entity 'anti-infective' named entity 'drug' named entity 'risks' named entity 'drugs' named entity 'chemotherapy' named entity 'USE' named entity 'POTENTIAL' named entity 'EFFECTIVE' named entity 'SUCCESSES' named entity 'INHALED' named entity 'PHARMACOKINETICS' named entity 'ANTI-INFECTIVE AGENTS' named entity 'DEVELOPMENTAL' named entity 'SYSTEMIC TOXICITY' named entity 'HUMANS' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'INHALED' named entity 'SYSTEMIC' named entity 'FUNGAL PATHOGENS' named entity 'CHEMOTHERAPY' named entity 'CHALLENGES' named entity 'ROAD' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'PROVIDES' named entity 'DOSAGES' named entity 'SUBOPTIMAL' named entity 'BENEFIT' named entity 'DELIVERY' named entity 'TREATMENT' named entity 'THEIR' named entity 'ANTI-INFECTIVE DRUGS' named entity 'DRUG EXPOSURE' named entity 'ILLNESSES' named entity 'ASSOCIATED WITH' named entity 'PARTICULAR' named entity 'VIRAL' named entity 'APPROVED' named entity 'STRATEGIES' named entity 'DIRECTLY' named entity 'DRUG DELIVERY' named entity 'REVIEW' named entity 'THERAPEUTIC' named entity 'PULMONARY' named entity 'SAFETY' named entity 'INHALATION' named entity 'CAUSES' named entity 'ONE OF' named entity 'RISKS' named entity 'DATE' named entity 'NOVEL' named entity 'PRIMARY SITE' named entity 'COMMON' named entity 'PROPHYLAXIS' named entity 'BACTERIAL' named entity 'PHARMACOKINETIC' named entity 'ATTENTION' named entity 'PROPERTIES' named entity 'SUFFICIENT' covid:arg/844be100b06408734894f48a4db56a05ba260621 named entity 'SITE OF INFECTION' named entity 'site' named entity 'pharmacokinetic' named entity 'prophylaxis' named entity 'viral' named entity 'systemic' named entity 'respiratory tract infections' named entity 'fungal pathogens' named entity 'prophylaxis' named entity 'drug delivery' named entity 'road ahead' named entity 'respiratory tract infections' named entity 'cough' named entity 'systemic administration' named entity 'hemorrhagic fever with renal syndrome' named entity 'Aerosolizing' named entity 'saline' named entity 'aztreonam'

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